STRUCTURED PEPTIDE PROCESSING

The invention relates to a method for modifying one or more peptide ligands, comprising polypeptides covalently linked to a molecular scaffold at two or more amino acid residues, comprising the steps of providing one or more peptide ligands, wherein the polypeptide comprises two or more reactive gro...

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Hauptverfasser:	LOAKES, DAVID, VAYSBURD, MARINA, HEINIS, CHRISTIAN, WINTER, GREGORY PAUL, BERNARD, ELISE
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMBINATORIAL CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE
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creator	LOAKES, DAVID VAYSBURD, MARINA HEINIS, CHRISTIAN WINTER, GREGORY PAUL BERNARD, ELISE
description	The invention relates to a method for modifying one or more peptide ligands, comprising polypeptides covalently linked to a molecular scaffold at two or more amino acid residues, comprising the steps of providing one or more peptide ligands, wherein the polypeptide comprises two or more reactive groups which form a covalent linkage to the molecular scaffold, and at least one loop which comprises a sequence of two or more amino acids subtended between two of said reactive groups; exposing the peptide ligands to one or more proteases; and sorting the ligands according to the extent of proteolytic cleavage. L'invention porte sur un procédé de modification d'un ou de plusieurs ligands peptidiques, comprenant des polypeptides liés de façon covalente à un échafaudage moléculaire au niveau de deux résidus d'acides aminés ou plus, le procédé comprend les étapes consistant à se procurer un ou plusieurs ligands peptidiques, le polypeptide comprenant deux groupes réactifs ou plus qui forment une liaison covalente avec l'échafaudage moléculaire, et au moins une boucle qui comprend une séquence de deux acides aminés ou plus sous-tendus entre deux desdits groupes réactifs ; exposer les ligands peptidiques à une ou plusieurs protéases ; et trier les ligands selon l'étendue du clivage protéolytique.
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L'invention porte sur un procédé de modification d'un ou de plusieurs ligands peptidiques, comprenant des polypeptides liés de façon covalente à un échafaudage moléculaire au niveau de deux résidus d'acides aminés ou plus, le procédé comprend les étapes consistant à se procurer un ou plusieurs ligands peptidiques, le polypeptide comprenant deux groupes réactifs ou plus qui forment une liaison covalente avec l'échafaudage moléculaire, et au moins une boucle qui comprend une séquence de deux acides aminés ou plus sous-tendus entre deux desdits groupes réactifs ; exposer les ligands peptidiques à une ou plusieurs protéases ; et trier les ligands selon l'étendue du clivage protéolytique.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMBINATORIAL CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; COMPOSITIONS THEREOF ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; CULTURE MEDIA ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES ; MEASURING ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PHYSICS ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; TESTING ; VINEGAR ; WINE</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190507&DB=EPODOC&CC=CA&NR=2750969C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76294</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190507&DB=EPODOC&CC=CA&NR=2750969C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LOAKES, DAVID</creatorcontrib><creatorcontrib>VAYSBURD, MARINA</creatorcontrib><creatorcontrib>HEINIS, CHRISTIAN</creatorcontrib><creatorcontrib>WINTER, GREGORY PAUL</creatorcontrib><creatorcontrib>BERNARD, ELISE</creatorcontrib><title>STRUCTURED PEPTIDE PROCESSING</title><description>The invention relates to a method for modifying one or more peptide ligands, comprising polypeptides covalently linked to a molecular scaffold at two or more amino acid residues, comprising the steps of providing one or more peptide ligands, wherein the polypeptide comprises two or more reactive groups which form a covalent linkage to the molecular scaffold, and at least one loop which comprises a sequence of two or more amino acids subtended between two of said reactive groups; exposing the peptide ligands to one or more proteases; and sorting the ligands according to the extent of proteolytic cleavage. L'invention porte sur un procédé de modification d'un ou de plusieurs ligands peptidiques, comprenant des polypeptides liés de façon covalente à un échafaudage moléculaire au niveau de deux résidus d'acides aminés ou plus, le procédé comprend les étapes consistant à se procurer un ou plusieurs ligands peptidiques, le polypeptide comprenant deux groupes réactifs ou plus qui forment une liaison covalente avec l'échafaudage moléculaire, et au moins une boucle qui comprend une séquence de deux acides aminés ou plus sous-tendus entre deux desdits groupes réactifs ; exposer les ligands peptidiques à une ou plusieurs protéases ; et trier les ligands selon l'étendue du clivage protéolytique.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMBINATORIAL CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>COMPOSITIONS THEREOF</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES</subject><subject>MEASURING</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PHYSICS</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZJANDgkKdQ4JDXJ1UQhwDQjxdHFVCAjyd3YNDvb0c-dhYE1LzClO5YXS3Azybq4hzh66qQX58anFBYnJqXmpJfHOjkbmpgaWZpbOxoRVAAA1fCCT</recordid><startdate>20190507</startdate><enddate>20190507</enddate><creator>LOAKES, DAVID</creator><creator>VAYSBURD, MARINA</creator><creator>HEINIS, CHRISTIAN</creator><creator>WINTER, GREGORY PAUL</creator><creator>BERNARD, ELISE</creator><scope>EVB</scope></search><sort><creationdate>20190507</creationdate><title>STRUCTURED PEPTIDE PROCESSING</title><author>LOAKES, DAVID ; 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exposing the peptide ligands to one or more proteases; and sorting the ligands according to the extent of proteolytic cleavage. L'invention porte sur un procédé de modification d'un ou de plusieurs ligands peptidiques, comprenant des polypeptides liés de façon covalente à un échafaudage moléculaire au niveau de deux résidus d'acides aminés ou plus, le procédé comprend les étapes consistant à se procurer un ou plusieurs ligands peptidiques, le polypeptide comprenant deux groupes réactifs ou plus qui forment une liaison covalente avec l'échafaudage moléculaire, et au moins une boucle qui comprend une séquence de deux acides aminés ou plus sous-tendus entre deux desdits groupes réactifs ; exposer les ligands peptidiques à une ou plusieurs protéases ; et trier les ligands selon l'étendue du clivage protéolytique.</abstract><oa>free_for_read</oa></addata></record>
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subjects	BEER BIOCHEMISTRY CHEMISTRY COMBINATORIAL CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE
title	STRUCTURED PEPTIDE PROCESSING
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