A METHOD FOR INCREASING PROTEIN EXPRESSION IN CELLS COMPRISING REDUCTION IN RNASE L CLEAVAGE SITES

The present invention relates to a method for increasing the expression of a protein in cells, preferably in eukaryot-ic cells, by reducing the number of RNase L cleavage sites in the coding and/or non-coding region of the nucleic acid sequence of said protein. Furthermore, it relates to nucleic aci...

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1. Verfasser:	KHABAR, KHALID S. ABU
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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creator	KHABAR, KHALID S. ABU
description	The present invention relates to a method for increasing the expression of a protein in cells, preferably in eukaryot-ic cells, by reducing the number of RNase L cleavage sites in the coding and/or non-coding region of the nucleic acid sequence of said protein. Furthermore, it relates to nucleic acid sequences exhibiting a reduced number of RNase L cleavage sites as well as to the proteins translated from such sequences. La présente invention porte sur un procédé pour l'augmentation de l'expression d'une protéine dans des cellules, de préférence dans des cellules eucaryotes, par réduction du nombre de sites de coupure par L'ARNase L dans la région codante et/ou non codante de la séquence d'acide nucléique de ladite protéine. En outre, l'invention porte sur des séquences d'acide nucléique présentant un nombre réduit de sites de coupure par l'ARNase L, ainsi que sur les protéines traduites à partir de telles séquences.
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ABU</creatorcontrib><description>The present invention relates to a method for increasing the expression of a protein in cells, preferably in eukaryot-ic cells, by reducing the number of RNase L cleavage sites in the coding and/or non-coding region of the nucleic acid sequence of said protein. Furthermore, it relates to nucleic acid sequences exhibiting a reduced number of RNase L cleavage sites as well as to the proteins translated from such sequences. La présente invention porte sur un procédé pour l'augmentation de l'expression d'une protéine dans des cellules, de préférence dans des cellules eucaryotes, par réduction du nombre de sites de coupure par L'ARNase L dans la région codante et/ou non codante de la séquence d'acide nucléique de ladite protéine. 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ABU</creatorcontrib><title>A METHOD FOR INCREASING PROTEIN EXPRESSION IN CELLS COMPRISING REDUCTION IN RNASE L CLEAVAGE SITES</title><description>The present invention relates to a method for increasing the expression of a protein in cells, preferably in eukaryot-ic cells, by reducing the number of RNase L cleavage sites in the coding and/or non-coding region of the nucleic acid sequence of said protein. Furthermore, it relates to nucleic acid sequences exhibiting a reduced number of RNase L cleavage sites as well as to the proteins translated from such sequences. La présente invention porte sur un procédé pour l'augmentation de l'expression d'une protéine dans des cellules, de préférence dans des cellules eucaryotes, par réduction du nombre de sites de coupure par L'ARNase L dans la région codante et/ou non codante de la séquence d'acide nucléique de ladite protéine. 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ABU</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KHABAR, KHALID S. ABU</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>A METHOD FOR INCREASING PROTEIN EXPRESSION IN CELLS COMPRISING REDUCTION IN RNASE L CLEAVAGE SITES</title><date>2017-06-06</date><risdate>2017</risdate><abstract>The present invention relates to a method for increasing the expression of a protein in cells, preferably in eukaryot-ic cells, by reducing the number of RNase L cleavage sites in the coding and/or non-coding region of the nucleic acid sequence of said protein. Furthermore, it relates to nucleic acid sequences exhibiting a reduced number of RNase L cleavage sites as well as to the proteins translated from such sequences. La présente invention porte sur un procédé pour l'augmentation de l'expression d'une protéine dans des cellules, de préférence dans des cellules eucaryotes, par réduction du nombre de sites de coupure par L'ARNase L dans la région codante et/ou non codante de la séquence d'acide nucléique de ladite protéine. En outre, l'invention porte sur des séquences d'acide nucléique présentant un nombre réduit de sites de coupure par l'ARNase L, ainsi que sur les protéines traduites à partir de telles séquences.</abstract><oa>free_for_read</oa></addata></record>
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subjects	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
title	A METHOD FOR INCREASING PROTEIN EXPRESSION IN CELLS COMPRISING REDUCTION IN RNASE L CLEAVAGE SITES
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