AABB-POLY(DEPSIPEPTIDE) BIODEGRADABLE POLYMERS AND METHODS OF USE
The invention provides AABB-poly(depsipeptide)s (AABB-PDPs), a class of biodegradable polymers composed of a-amino and a-hydroxy acids with material properties suitable for biomedical applications. These AABB-PDPs belong to the family of amino acid- based poly(ester amide)s (PEAs), which are charact...
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| creator | TUGUSHI, DAVID KATSARAVA, RAMAZ GOMURASHVILI, ZAZA D OCHKHIKIDZE, NATIA |
| description | The invention provides AABB-poly(depsipeptide)s (AABB-PDPs), a class of biodegradable polymers composed of a-amino and a-hydroxy acids with material properties suitable for biomedical applications. These AABB-PDPs belong to the family of amino acid- based poly(ester amide)s (PEAs), which are characterized by the presence of alternating ester and amide functionalities. Containing four ether groups per basic unit, these polymers degrade rapidly by biotic or abiotic hydrolytic action to release dispersed bioactive agents at a controlled delivery rate, are non-toxic, produce digestible breakdown products, and are easy to fabricate by solution polycondensation. |
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These AABB-PDPs belong to the family of amino acid- based poly(ester amide)s (PEAs), which are characterized by the presence of alternating ester and amide functionalities. 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| subjects | CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES DISINFECTION, STERILISATION, OR DEODORISATION OF AIR HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | AABB-POLY(DEPSIPEPTIDE) BIODEGRADABLE POLYMERS AND METHODS OF USE |
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