PHARMACEUTICAL COMPOSITION COMPRISING RIMEPORIDE FOR TREATING DISEASES ASSOCIATED WITH INSULIN RESISTANCE AND BETA-CELL DYSFUNCTION
The invention relates to a pharmaceutical composition comprising as active ingredient an effective amount of 2-Methyl-4,5-di-(methylsulfonyl)-benzoyl-guanidine, or derivatives thereof, for the prophylaxis and therapy of Type II diabetes mellitus, the Metabolic syndrome, diabetic nephropathy and/or n...
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| creator | BRAENDLE, MARIAN BETZ, ULRICH SCHOLZ, WOLFGANG BEIER, NORBERT |
| description | The invention relates to a pharmaceutical composition comprising as active ingredient an effective amount of 2-Methyl-4,5-di-(methylsulfonyl)-benzoyl-guanidine, or derivatives thereof, for the prophylaxis and therapy of Type II diabetes mellitus, the Metabolic syndrome, diabetic nephropathy and/or neuropathy. Another object of the invention concerns the use of 2-Methyl-4,5-di-(methylsulfonyl)-benzoyl-guanidine, or derivatives thereof, for the enhancement of insulin sensitivity and the preservation or increase of O-cell compensation.
La présente invention concerne une composition pharmaceutique renfermant comme principe actif une quantité efficace de 2-méthyl-4,5-di- (méthylsulfonyl)- benzoyl-guanidine ou ses dérivés, et indiquée pour la prophylaxie et la thérapie du diabète de type II, le syndrome métabolique, ainsi que pour la néphropathie diabétique et/ou la neuropathie diabétique. Un autre objet de linvention concerne lutilisation de la 2-méthyl-4,5-di-(méthylsulfonyl)- benzoyl-guanidine ou de ses dérivés, pour lamplification de la sensibilité à linsuline et la conservation ou laugmentation de la compensation des cellules ß. |
| format | Patent |
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La présente invention concerne une composition pharmaceutique renfermant comme principe actif une quantité efficace de 2-méthyl-4,5-di- (méthylsulfonyl)- benzoyl-guanidine ou ses dérivés, et indiquée pour la prophylaxie et la thérapie du diabète de type II, le syndrome métabolique, ainsi que pour la néphropathie diabétique et/ou la neuropathie diabétique. Un autre objet de linvention concerne lutilisation de la 2-méthyl-4,5-di-(méthylsulfonyl)- benzoyl-guanidine ou de ses dérivés, pour lamplification de la sensibilité à linsuline et la conservation ou laugmentation de la compensation des cellules ß.</description><language>eng ; fre</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2016</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160920&DB=EPODOC&CC=CA&NR=2725209C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160920&DB=EPODOC&CC=CA&NR=2725209C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BRAENDLE, MARIAN</creatorcontrib><creatorcontrib>BETZ, ULRICH</creatorcontrib><creatorcontrib>SCHOLZ, WOLFGANG</creatorcontrib><creatorcontrib>BEIER, NORBERT</creatorcontrib><title>PHARMACEUTICAL COMPOSITION COMPRISING RIMEPORIDE FOR TREATING DISEASES ASSOCIATED WITH INSULIN RESISTANCE AND BETA-CELL DYSFUNCTION</title><description>The invention relates to a pharmaceutical composition comprising as active ingredient an effective amount of 2-Methyl-4,5-di-(methylsulfonyl)-benzoyl-guanidine, or derivatives thereof, for the prophylaxis and therapy of Type II diabetes mellitus, the Metabolic syndrome, diabetic nephropathy and/or neuropathy. Another object of the invention concerns the use of 2-Methyl-4,5-di-(methylsulfonyl)-benzoyl-guanidine, or derivatives thereof, for the enhancement of insulin sensitivity and the preservation or increase of O-cell compensation.
La présente invention concerne une composition pharmaceutique renfermant comme principe actif une quantité efficace de 2-méthyl-4,5-di- (méthylsulfonyl)- benzoyl-guanidine ou ses dérivés, et indiquée pour la prophylaxie et la thérapie du diabète de type II, le syndrome métabolique, ainsi que pour la néphropathie diabétique et/ou la neuropathie diabétique. Un autre objet de linvention concerne lutilisation de la 2-méthyl-4,5-di-(méthylsulfonyl)- benzoyl-guanidine ou de ses dérivés, pour lamplification de la sensibilité à linsuline et la conservation ou laugmentation de la compensation des cellules ß.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2016</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFjUEKwkAMRbtxIeoZzAUEqYi4jJnUBqYzZZIirkqRcSUq6A28uCjuXf3H48EfF6-2xtQgcWdC6IFi00YVkxi-nEQl7CFJw21M4hiqmMASo328E2VUVkDVSILGDg5iNUjQzkuAxCpqGIgBg4MdGy6IvQd31KoL9DmaFqPzcHnk2W8nxbxio3qR77c-P-7DKV_zsycsN-W6XG5p9b94A6XYPL8</recordid><startdate>20160920</startdate><enddate>20160920</enddate><creator>BRAENDLE, MARIAN</creator><creator>BETZ, ULRICH</creator><creator>SCHOLZ, WOLFGANG</creator><creator>BEIER, NORBERT</creator><scope>EVB</scope></search><sort><creationdate>20160920</creationdate><title>PHARMACEUTICAL COMPOSITION COMPRISING RIMEPORIDE FOR TREATING DISEASES ASSOCIATED WITH INSULIN RESISTANCE AND BETA-CELL DYSFUNCTION</title><author>BRAENDLE, MARIAN ; BETZ, ULRICH ; SCHOLZ, WOLFGANG ; BEIER, NORBERT</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2725209C3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2016</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>BRAENDLE, MARIAN</creatorcontrib><creatorcontrib>BETZ, ULRICH</creatorcontrib><creatorcontrib>SCHOLZ, WOLFGANG</creatorcontrib><creatorcontrib>BEIER, NORBERT</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BRAENDLE, MARIAN</au><au>BETZ, ULRICH</au><au>SCHOLZ, WOLFGANG</au><au>BEIER, NORBERT</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PHARMACEUTICAL COMPOSITION COMPRISING RIMEPORIDE FOR TREATING DISEASES ASSOCIATED WITH INSULIN RESISTANCE AND BETA-CELL DYSFUNCTION</title><date>2016-09-20</date><risdate>2016</risdate><abstract>The invention relates to a pharmaceutical composition comprising as active ingredient an effective amount of 2-Methyl-4,5-di-(methylsulfonyl)-benzoyl-guanidine, or derivatives thereof, for the prophylaxis and therapy of Type II diabetes mellitus, the Metabolic syndrome, diabetic nephropathy and/or neuropathy. Another object of the invention concerns the use of 2-Methyl-4,5-di-(methylsulfonyl)-benzoyl-guanidine, or derivatives thereof, for the enhancement of insulin sensitivity and the preservation or increase of O-cell compensation.
La présente invention concerne une composition pharmaceutique renfermant comme principe actif une quantité efficace de 2-méthyl-4,5-di- (méthylsulfonyl)- benzoyl-guanidine ou ses dérivés, et indiquée pour la prophylaxie et la thérapie du diabète de type II, le syndrome métabolique, ainsi que pour la néphropathie diabétique et/ou la neuropathie diabétique. Un autre objet de linvention concerne lutilisation de la 2-méthyl-4,5-di-(méthylsulfonyl)- benzoyl-guanidine ou de ses dérivés, pour lamplification de la sensibilité à linsuline et la conservation ou laugmentation de la compensation des cellules ß.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | PHARMACEUTICAL COMPOSITION COMPRISING RIMEPORIDE FOR TREATING DISEASES ASSOCIATED WITH INSULIN RESISTANCE AND BETA-CELL DYSFUNCTION |
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