CROSSLINKED POLYALKYLENEIMINE HYDROGELS WITH TUNABLE DEGRADATION RATES

One aspect of the present invention relates to methods of sealing a wound or tissue plane or filling a void space, or securing meshes, films or other devices within the body. In certain embodiments, the wound is an ophthalmic, pleural or dural wound, or a hernia repair mesh. Remarkably, disclosed he...

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Hauptverfasser:	BUTLIN, JARED, CARNAHAN, MICHAEL A
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G CHEMISTRY COMPOSITIONS BASED THEREON GENERAL PROCESSES OF COMPOUNDING HUMAN NECESSITIES HYGIENE MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES THEIR PREPARATION OR CHEMICAL WORKING-UP WORKING-UP
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creator	BUTLIN, JARED CARNAHAN, MICHAEL A
description	One aspect of the present invention relates to methods of sealing a wound or tissue plane or filling a void space, or securing meshes, films or other devices within the body. In certain embodiments, the wound is an ophthalmic, pleural or dural wound, or a hernia repair mesh. Remarkably, disclosed herein is the discovery that the use of certain crosslinkers in combination with polyalkyleneimines at specific concentrations can result in hydrogels with tunable degradation properties. Cette invention concerne des procédés de fermeture dune plaie, dun tissu, ou de comblement dun espace vide, ou de fixation de mailles, de films ou dautres dispositifs à lintérieur de lorganisme. Dans certains modes de réalisation, la plaie est une plaie ophtalmique, pleurale ou durale, ou une maille de réparation de hernie. Linvention concerne la découverte remarquable selon laquelle lutilisation de certains agents de réticulation associés avec des polyalkylèneimines à des concentrations spécifiques peut aboutir à des hydrogels aux propriétés de dégradation ajustables.
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subjects	AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G CHEMISTRY COMPOSITIONS BASED THEREON GENERAL PROCESSES OF COMPOUNDING HUMAN NECESSITIES HYGIENE MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES THEIR PREPARATION OR CHEMICAL WORKING-UP WORKING-UP
title	CROSSLINKED POLYALKYLENEIMINE HYDROGELS WITH TUNABLE DEGRADATION RATES
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