AGENTS TARGETING CD138 AND USES THEREOF

AGENTS TARGETING CD138 AND USES THEREOF

Disclosed is a human murine chimeric antibody which substantially retains the antigen binding region of its murine counterpart and displays improved binding affinities to the antigen and/or more homogenous binding to target cells. La présente invention concerne un anticorps chimérique murin/humain q...

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Bibliographische Detailangaben
Hauptverfasser: DAELKEN, BENJAMIN, GERMER, MATTHIAS, ZENG, STEFFEN, UHEREK, CHRISTOPH, AIGNER, SILKE, KRAUS, ELMAR, BRUECHER, CHRISTOPH, SCHULZ, GREGOR, OSTERROTH, FRANK
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Disclosed is a human murine chimeric antibody which substantially retains the antigen binding region of its murine counterpart and displays improved binding affinities to the antigen and/or more homogenous binding to target cells. La présente invention concerne un anticorps chimérique murin/humain qui conserve sensiblement la région de liaison à l'antigène de son homologue murin et présente des affinités de liaison améliorées à l'antigène et/ou une liaison plus homogène aux cellules cibles.