PHENYL AMINO PYRIMIDINE COMPOUNDS AND USES THEREOF
The present disclosure relates to phenyl amino pyrimidine compounds comprising the following general formula: (See Formula I) which are inhibitors of JAK kinases. In particular the compounds are selective for JAK2 kinases as compared to JAK3. La présente invention concerne des composés de phénylamin...
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| creator | DONOHUE, ANDREW CRAIG NGYGEN, THAO LIEN THI WILKS, ANDREW FREDERICK BURNS, CHRISTOPHER JOHN FEUTRILL, JOHN THOMAS ZENG, JUN |
| description | The present disclosure relates to phenyl amino pyrimidine compounds comprising the following general formula: (See Formula I) which are inhibitors of JAK kinases. In particular the compounds are selective for JAK2 kinases as compared to JAK3.
La présente invention concerne des composés de phénylamino pyrimidine qui sont des inhibiteurs des protéines kinases y compris des kinases JAK. Plus particulièrement les composés sont sélectifs contre les kinases JAK2. Les inhibiteurs des kinases peuvent être utilisés dans le traitement des maladies associées aux kinases telles que les maladies immunologiques et inflammatoires y compris les transplantations d'organe; les maladies hyperprolifératives telles que le cancer et les syndromes myéloprolifératifs; les maladies virales; les maladies métaboliques et les maladies vasculaires. |
| format | Patent |
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La présente invention concerne des composés de phénylamino pyrimidine qui sont des inhibiteurs des protéines kinases y compris des kinases JAK. Plus particulièrement les composés sont sélectifs contre les kinases JAK2. Les inhibiteurs des kinases peuvent être utilisés dans le traitement des maladies associées aux kinases telles que les maladies immunologiques et inflammatoires y compris les transplantations d'organe; les maladies hyperprolifératives telles que le cancer et les syndromes myéloprolifératifs; les maladies virales; les maladies métaboliques et les maladies vasculaires.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170103&DB=EPODOC&CC=CA&NR=2702650C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170103&DB=EPODOC&CC=CA&NR=2702650C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>DONOHUE, ANDREW CRAIG</creatorcontrib><creatorcontrib>NGYGEN, THAO LIEN THI</creatorcontrib><creatorcontrib>WILKS, ANDREW FREDERICK</creatorcontrib><creatorcontrib>BURNS, CHRISTOPHER JOHN</creatorcontrib><creatorcontrib>FEUTRILL, JOHN THOMAS</creatorcontrib><creatorcontrib>ZENG, JUN</creatorcontrib><title>PHENYL AMINO PYRIMIDINE COMPOUNDS AND USES THEREOF</title><description>The present disclosure relates to phenyl amino pyrimidine compounds comprising the following general formula: (See Formula I) which are inhibitors of JAK kinases. In particular the compounds are selective for JAK2 kinases as compared to JAK3.
La présente invention concerne des composés de phénylamino pyrimidine qui sont des inhibiteurs des protéines kinases y compris des kinases JAK. Plus particulièrement les composés sont sélectifs contre les kinases JAK2. Les inhibiteurs des kinases peuvent être utilisés dans le traitement des maladies associées aux kinases telles que les maladies immunologiques et inflammatoires y compris les transplantations d'organe; les maladies hyperprolifératives telles que le cancer et les syndromes myéloprolifératifs; les maladies virales; les maladies métaboliques et les maladies vasculaires.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDAK8HD1i_RRcPT19PNXCIgM8vT1dPH0c1Vw9vcN8A_1cwlWcPRzUQgNdg1WCPFwDXL1d-NhYE1LzClO5YXS3Azybq4hzh66qQX58anFBYnJqXmpJfHOjkbmBkZmpgbOxoRVAADwYSYB</recordid><startdate>20170103</startdate><enddate>20170103</enddate><creator>DONOHUE, ANDREW CRAIG</creator><creator>NGYGEN, THAO LIEN THI</creator><creator>WILKS, ANDREW FREDERICK</creator><creator>BURNS, CHRISTOPHER JOHN</creator><creator>FEUTRILL, JOHN THOMAS</creator><creator>ZENG, JUN</creator><scope>EVB</scope></search><sort><creationdate>20170103</creationdate><title>PHENYL AMINO PYRIMIDINE COMPOUNDS AND USES THEREOF</title><author>DONOHUE, ANDREW CRAIG ; NGYGEN, THAO LIEN THI ; WILKS, ANDREW FREDERICK ; BURNS, CHRISTOPHER JOHN ; FEUTRILL, JOHN THOMAS ; ZENG, JUN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2702650C3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2017</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>DONOHUE, ANDREW CRAIG</creatorcontrib><creatorcontrib>NGYGEN, THAO LIEN THI</creatorcontrib><creatorcontrib>WILKS, ANDREW FREDERICK</creatorcontrib><creatorcontrib>BURNS, CHRISTOPHER JOHN</creatorcontrib><creatorcontrib>FEUTRILL, JOHN THOMAS</creatorcontrib><creatorcontrib>ZENG, JUN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>DONOHUE, ANDREW CRAIG</au><au>NGYGEN, THAO LIEN THI</au><au>WILKS, ANDREW FREDERICK</au><au>BURNS, CHRISTOPHER JOHN</au><au>FEUTRILL, JOHN THOMAS</au><au>ZENG, JUN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PHENYL AMINO PYRIMIDINE COMPOUNDS AND USES THEREOF</title><date>2017-01-03</date><risdate>2017</risdate><abstract>The present disclosure relates to phenyl amino pyrimidine compounds comprising the following general formula: (See Formula I) which are inhibitors of JAK kinases. In particular the compounds are selective for JAK2 kinases as compared to JAK3.
La présente invention concerne des composés de phénylamino pyrimidine qui sont des inhibiteurs des protéines kinases y compris des kinases JAK. Plus particulièrement les composés sont sélectifs contre les kinases JAK2. Les inhibiteurs des kinases peuvent être utilisés dans le traitement des maladies associées aux kinases telles que les maladies immunologiques et inflammatoires y compris les transplantations d'organe; les maladies hyperprolifératives telles que le cancer et les syndromes myéloprolifératifs; les maladies virales; les maladies métaboliques et les maladies vasculaires.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | PHENYL AMINO PYRIMIDINE COMPOUNDS AND USES THEREOF |
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