NOVEL METHOD FOR THE SYNTHESIS OF ANTICANCER (POLY)AMINOALKYLAMINOACETAMIDE DERIVATIVES OF EPIPODOPHYLLOTOXIN
The invention relates to a novel method for preparing (poly)aminoalkylaminoacetamide compounds of epipodophyllotoxin, which can be used in therapeutics as anticancer agents. The invention includes a step comprising the condensation of a primary amine reactant, the amine functions of which are not pr...
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| creator | IMBERT, THIERRY GUMINSKI, YVES GROUSSEAUD, MARTIAL |
| description | The invention relates to a novel method for preparing (poly)aminoalkylaminoacetamide compounds of epipodophyllotoxin, which can be used in therapeutics as anticancer agents. The invention includes a step comprising the condensation of a primary amine reactant, the amine functions of which are not protected, with 4ß-chloroacetamido-4'-epipodophyllotoxin in an aprotic polar organic solvent.
La présente invention décrit un nouveau procédé de préparation des composés (poly)aminoalkylaminoacétamide d'épipodophyllotoxine, utiles pour leurs applications en thérapeutique comme agents anticancéreux. Ce procédé comprend une étape de condensation d'un réactif aminé primaire dont les fonctions amine ne sont pas protégées avec le 4.beta.-chloroacétamido-4'-épipodophyllotoxine dans un solvant organique polaire aprotique. |
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La présente invention décrit un nouveau procédé de préparation des composés (poly)aminoalkylaminoacétamide d'épipodophyllotoxine, utiles pour leurs applications en thérapeutique comme agents anticancéreux. Ce procédé comprend une étape de condensation d'un réactif aminé primaire dont les fonctions amine ne sont pas protégées avec le 4.beta.-chloroacétamido-4'-épipodophyllotoxine dans un solvant organique polaire aprotique.</description><language>eng ; fre</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2013</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20131119&DB=EPODOC&CC=CA&NR=2700161C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20131119&DB=EPODOC&CC=CA&NR=2700161C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>IMBERT, THIERRY</creatorcontrib><creatorcontrib>GUMINSKI, YVES</creatorcontrib><creatorcontrib>GROUSSEAUD, MARTIAL</creatorcontrib><title>NOVEL METHOD FOR THE SYNTHESIS OF ANTICANCER (POLY)AMINOALKYLAMINOACETAMIDE DERIVATIVES OF EPIPODOPHYLLOTOXIN</title><description>The invention relates to a novel method for preparing (poly)aminoalkylaminoacetamide compounds of epipodophyllotoxin, which can be used in therapeutics as anticancer agents. The invention includes a step comprising the condensation of a primary amine reactant, the amine functions of which are not protected, with 4ß-chloroacetamido-4'-epipodophyllotoxin in an aprotic polar organic solvent.
La présente invention décrit un nouveau procédé de préparation des composés (poly)aminoalkylaminoacétamide d'épipodophyllotoxine, utiles pour leurs applications en thérapeutique comme agents anticancéreux. Ce procédé comprend une étape de condensation d'un réactif aminé primaire dont les fonctions amine ne sont pas protégées avec le 4.beta.-chloroacétamido-4'-épipodophyllotoxine dans un solvant organique polaire aprotique.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2013</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFiz0LwjAQQLs4iPobvFEHoVXQOSRXchhzoT2KmUqROPlRqP8fi7o7vTe8N83unht0cEKxbKDkCsQi1NGPqKkGLkF5Ia28xgpWgV1cqxN5Vu4Y3dc0yigGwWBFjRJq8DNioMCGg43OsfCZ_DybXLvbkBY_zrJliaLtJvXPNg19d0mP9Gq12h7yvNgXeve_eAOZzjas</recordid><startdate>20131119</startdate><enddate>20131119</enddate><creator>IMBERT, THIERRY</creator><creator>GUMINSKI, YVES</creator><creator>GROUSSEAUD, MARTIAL</creator><scope>EVB</scope></search><sort><creationdate>20131119</creationdate><title>NOVEL METHOD FOR THE SYNTHESIS OF ANTICANCER (POLY)AMINOALKYLAMINOACETAMIDE DERIVATIVES OF EPIPODOPHYLLOTOXIN</title><author>IMBERT, THIERRY ; GUMINSKI, YVES ; GROUSSEAUD, MARTIAL</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2700161C3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2013</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>IMBERT, THIERRY</creatorcontrib><creatorcontrib>GUMINSKI, YVES</creatorcontrib><creatorcontrib>GROUSSEAUD, MARTIAL</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>IMBERT, THIERRY</au><au>GUMINSKI, YVES</au><au>GROUSSEAUD, MARTIAL</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>NOVEL METHOD FOR THE SYNTHESIS OF ANTICANCER (POLY)AMINOALKYLAMINOACETAMIDE DERIVATIVES OF EPIPODOPHYLLOTOXIN</title><date>2013-11-19</date><risdate>2013</risdate><abstract>The invention relates to a novel method for preparing (poly)aminoalkylaminoacetamide compounds of epipodophyllotoxin, which can be used in therapeutics as anticancer agents. The invention includes a step comprising the condensation of a primary amine reactant, the amine functions of which are not protected, with 4ß-chloroacetamido-4'-epipodophyllotoxin in an aprotic polar organic solvent.
La présente invention décrit un nouveau procédé de préparation des composés (poly)aminoalkylaminoacétamide d'épipodophyllotoxine, utiles pour leurs applications en thérapeutique comme agents anticancéreux. Ce procédé comprend une étape de condensation d'un réactif aminé primaire dont les fonctions amine ne sont pas protégées avec le 4.beta.-chloroacétamido-4'-épipodophyllotoxine dans un solvant organique polaire aprotique.</abstract><oa>free_for_read</oa></addata></record> |
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| title | NOVEL METHOD FOR THE SYNTHESIS OF ANTICANCER (POLY)AMINOALKYLAMINOACETAMIDE DERIVATIVES OF EPIPODOPHYLLOTOXIN |
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