N-(2-(HETARYL)ARYL)ARYLSULFONAMIDES AND N-(2-(HETARYL)HETARYL)ARYLSULFONAMIDES

Compounds are provided that act as potent antagonists of the CCR9 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR9. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, meth...

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Bibliographische Detailangaben
Hauptverfasser:	POWERS, JAY, CHARVAT, TREVOR T, MELIKIAN, ANITA, THOMAS, WILLIAM D, NOVACK, AARON, PUNNA, SREENIVAS, UNGASHE, SOLOMON, HU, CHENG, ZHANG, PENGLIE, SULLIVAN, EDWARD J, PENNELL, ANDREW M.K
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Compounds are provided that act as potent antagonists of the CCR9 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR9. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR9-mediated diseases, and as controls in assays for the identification of CCR9 antagonists. Cette invention concerne des composés qui agissent comme de puissants antagonistes du récepteur CCR9. Les études précliniques démontrent que ces composés sont utiles pour traiter l'inflammation, caractéristique du CCR9. Ces composés sont généralement des dérivés arylsulfonamides et sont utilisés dans les compositions pharmaceutiques, dans les procédés de traitement des maladies associées au CCR9 et en tant que témoins dans les dosages d'identification des antagonistes du CCR9.