HIGH-AMYLOSE SODIUM CARBOXYMETHYL STARCH SUSTAINED RELEASE EXCIPIENT AND PROCESS FOR PREPARING THE SAME
A process for obtaining a spray-dried high amylose sodium carboxymethyl s tarch comprising a major fraction of amorphous form and optionally a minor f raction of crystalline V form, is provided. The process comprises providing an amorphous pregelatinized high amylose sodium carboxymethyl starch (HAS...
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| creator | BATAILLE, BERNARD BAYLAC, GILLES CARTILIER, LOUIS BROUILLET, FABIEN |
| description | A process for obtaining a spray-dried high amylose sodium carboxymethyl s tarch comprising a major fraction of amorphous form and optionally a minor f raction of crystalline V form, is provided. The process comprises providing an amorphous pregelatinized high amylose sodium carboxymethyl starch (HASCA) ; dispersing the amorphous pregelatinized HASCA in a solution comprising wat er and at least one first pharmaceutically acceptable organic solvent miscib le with water and suitable for spray-drying; and spray-drying the dispersion to obtain the spray-dried HASCA comprising a major fraction of amorphous fo rm and optionally a minor fraction of crystalline V form, in the form of a p owder. Also provided is a spray-dried HASCA sustained-release excipient. Thi s excipient is useful for preparing a tablet for the sustained-release of at least one drug. |
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The process comprises providing an amorphous pregelatinized high amylose sodium carboxymethyl starch (HASCA) ; dispersing the amorphous pregelatinized HASCA in a solution comprising wat er and at least one first pharmaceutically acceptable organic solvent miscib le with water and suitable for spray-drying; and spray-drying the dispersion to obtain the spray-dried HASCA comprising a major fraction of amorphous fo rm and optionally a minor fraction of crystalline V form, in the form of a p owder. Also provided is a spray-dried HASCA sustained-release excipient. 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| subjects | CHEMISTRY COMPOSITIONS BASED THEREON DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS POLYSACCHARIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES THEIR PREPARATION OR CHEMICAL WORKING-UP |
| title | HIGH-AMYLOSE SODIUM CARBOXYMETHYL STARCH SUSTAINED RELEASE EXCIPIENT AND PROCESS FOR PREPARING THE SAME |
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