SUSTAINED DELIVERY FORMULATIONS OF RISPERIDONE COMPOUNDS

The present invention relates to a risperidone sustained release delivery system for treatment of medical conditions relating delusional psychosis, schizophrenia, bipolar disorder, psychotic depression, obsessive-compulsion disorder, Tourette syndrome, and autistic spectrum disorders. The sustained...

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description The present invention relates to a risperidone sustained release delivery system for treatment of medical conditions relating delusional psychosis, schizophrenia, bipolar disorder, psychotic depression, obsessive-compulsion disorder, Tourette syndrome, and autistic spectrum disorders. The sustained release delivery system includes a flowable composition containing risperidone, a metabolite, or a prodrug thereof and an implant containing risperidone, a metabolite, or a prodrug thereof. The flowable composition may be injected into tissue whereupon it coagulates to become the solid or gel, monolithic implant. The flowable composition includes a biodegradable, thermoplastic polymer, an organic liquid, and risperidone, a metabolite, or a prodrug thereof. L'invention concerne un système d'administration à libération prolongée de rispéridone pour le traitement d'états médicaux en rapport avec la psychose délirante, la schizophrénie, les troubles bipolaires, la dépression psychotique, les troubles obsessionnels compulsifs, le syndrome de Gilles de la Tourette, et les troubles du spectre autistique. Le système d'administration à libération prolongée comprend une composition liquide contenant de la rispéridone, un métabolite, ou un promédicament de celle-ci et un implant contenant de la rispéridone, un métabolite, ou un promédicament de celle-ci. La composition liquide peut être injectée dans le tissu où il coagule pour devenir l'implant monolithique solide ou gélifié. La composition liquide comprend un polymère thermoplastique biodégradable, un liquide organique et de la rispéridone, un métabolite, ou un promédicament de celle-ci.
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subjects CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES
DISINFECTION, STERILISATION, OR DEODORISATION OF AIR
HUMAN NECESSITIES
HYGIENE
MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES
MEDICAL OR VETERINARY SCIENCE
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title SUSTAINED DELIVERY FORMULATIONS OF RISPERIDONE COMPOUNDS
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