ATORVASTATIN CALCIUM PROPYLENE GLYCOL SOLVATES

ATORVASTATIN CALCIUM PROPYLENE GLYCOL SOLVATES

The present application relates to atorvastatin calcium propylene glycol solvates and processes of preparing the same. The atorvastatin calcium propylene glycol solvates are crystalline and show high chemical and solid state stability, low hygroscopicity, and good flow properties.The solvates can be...

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Hauptverfasser: MURTHY, KESHAVA K.S, KOTIPALLI, UMA, DAQING, CHE, REY, ALLAN W, ZHAO, YAJUN, STRADIOTTO, DAVID A
Format: Patent
Sprache:eng ; fre
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator MURTHY, KESHAVA K.S
KOTIPALLI, UMA
DAQING, CHE
REY, ALLAN W
ZHAO, YAJUN
STRADIOTTO, DAVID A
description The present application relates to atorvastatin calcium propylene glycol solvates and processes of preparing the same. The atorvastatin calcium propylene glycol solvates are crystalline and show high chemical and solid state stability, low hygroscopicity, and good flow properties.The solvates can be efficiently prepared from various forms of atorvastatin and either (R), (S), or mixtures of (R) and (S) propylene glycol, and may be easily filtered and dried on an industrial scale.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title ATORVASTATIN CALCIUM PROPYLENE GLYCOL SOLVATES
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