ATORVASTATIN CALCIUM PROPYLENE GLYCOL SOLVATES

The present application relates to atorvastatin calcium propylene glycol solvates and processes of preparing the same. The atorvastatin calcium propylene glycol solvates are crystalline and show high chemical and solid state stability, low hygroscopicity, and good flow properties.The solvates can be...

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Bibliographische Detailangaben
Hauptverfasser:	MURTHY, KESHAVA K.S, KOTIPALLI, UMA, DAQING, CHE, REY, ALLAN W, ZHAO, YAJUN, STRADIOTTO, DAVID A
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present application relates to atorvastatin calcium propylene glycol solvates and processes of preparing the same. The atorvastatin calcium propylene glycol solvates are crystalline and show high chemical and solid state stability, low hygroscopicity, and good flow properties.The solvates can be efficiently prepared from various forms of atorvastatin and either (R), (S), or mixtures of (R) and (S) propylene glycol, and may be easily filtered and dried on an industrial scale.