3,4-DIHYDROPYRROLO[1,2-A]PYRAZIN-1-YL AMINES USEFUL AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS
The present invention relates to 4-aryl-6-piperazin-1-yl-3-substituted-pyridazines that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medici...
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| creator | MACDONALD, GREGOR JAMES LANGLOIS, XAVIER JEAN MICHEL BARTOLOME-NEBREDA, JOSE MANUEL VAN GOOL, MICHIEL LUC MARIA |
| description | The present invention relates to 4-aryl-6-piperazin-1-yl-3-substituted-pyridazines that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, forexample schizophrenia, by exerting an antipsychotic effect without motor side effects.
La présente invention porte sur des 4-aryl-6-pipérazin-1-yl-pyridazines substituées en position 3, qui sont des antagonistes du récepteur de la dopamine 2 se dissociant rapidement, sur des procédés de préparation de ces composés, sur des compositions pharmaceutiques comprenant ces composés comme ingrédient actif. Les composés trouvent utilité comme médicaments pour traiter ou prévenir des troubles du système nerveux central, par exemple la schizophrénie, en exerçant un effet anti-psychotique sans effets secondaires moteurs. |
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La présente invention porte sur des 4-aryl-6-pipérazin-1-yl-pyridazines substituées en position 3, qui sont des antagonistes du récepteur de la dopamine 2 se dissociant rapidement, sur des procédés de préparation de ces composés, sur des compositions pharmaceutiques comprenant ces composés comme ingrédient actif. Les composés trouvent utilité comme médicaments pour traiter ou prévenir des troubles du système nerveux central, par exemple la schizophrénie, en exerçant un effet anti-psychotique sans effets secondaires moteurs.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2015</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150331&DB=EPODOC&CC=CA&NR=2674752C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150331&DB=EPODOC&CC=CA&NR=2674752C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MACDONALD, GREGOR JAMES</creatorcontrib><creatorcontrib>LANGLOIS, XAVIER JEAN MICHEL</creatorcontrib><creatorcontrib>BARTOLOME-NEBREDA, JOSE MANUEL</creatorcontrib><creatorcontrib>VAN GOOL, MICHIEL LUC MARIA</creatorcontrib><title>3,4-DIHYDROPYRROLO[1,2-A]PYRAZIN-1-YL AMINES USEFUL AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS</title><description>The present invention relates to 4-aryl-6-piperazin-1-yl-3-substituted-pyridazines that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, forexample schizophrenia, by exerting an antipsychotic effect without motor side effects.
La présente invention porte sur des 4-aryl-6-pipérazin-1-yl-pyridazines substituées en position 3, qui sont des antagonistes du récepteur de la dopamine 2 se dissociant rapidement, sur des procédés de préparation de ces composés, sur des compositions pharmaceutiques comprenant ces composés comme ingrédient actif. Les composés trouvent utilité comme médicaments pour traiter ou prévenir des troubles du système nerveux central, par exemple la schizophrénie, en exerçant un effet anti-psychotique sans effets secondaires moteurs.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2015</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFykELgjAYgGEvHaL6DX0_wB2cpuePberANtk3DxYhEosOUYL9f5Lo3unlgXcd3dM4Y1LXvXS27Z2zjT0nMWd4WYQnbVjC-gbwqI0i6EiV3SKCEsmD1ERWaPTaVCBt-72Ag1NCtd46QOOxskaTp220uo2POex-3UT7UnlRszC9hjBP4zU8w3sQyPMiKw5cpP-PDz_ANLU</recordid><startdate>20150331</startdate><enddate>20150331</enddate><creator>MACDONALD, GREGOR JAMES</creator><creator>LANGLOIS, XAVIER JEAN MICHEL</creator><creator>BARTOLOME-NEBREDA, JOSE MANUEL</creator><creator>VAN GOOL, MICHIEL LUC MARIA</creator><scope>EVB</scope></search><sort><creationdate>20150331</creationdate><title>3,4-DIHYDROPYRROLO[1,2-A]PYRAZIN-1-YL AMINES USEFUL AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS</title><author>MACDONALD, GREGOR JAMES ; LANGLOIS, XAVIER JEAN MICHEL ; BARTOLOME-NEBREDA, JOSE MANUEL ; VAN GOOL, MICHIEL LUC MARIA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2674752C3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2015</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>MACDONALD, GREGOR JAMES</creatorcontrib><creatorcontrib>LANGLOIS, XAVIER JEAN MICHEL</creatorcontrib><creatorcontrib>BARTOLOME-NEBREDA, JOSE MANUEL</creatorcontrib><creatorcontrib>VAN GOOL, MICHIEL LUC MARIA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MACDONALD, GREGOR JAMES</au><au>LANGLOIS, XAVIER JEAN MICHEL</au><au>BARTOLOME-NEBREDA, JOSE MANUEL</au><au>VAN GOOL, MICHIEL LUC MARIA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>3,4-DIHYDROPYRROLO[1,2-A]PYRAZIN-1-YL AMINES USEFUL AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS</title><date>2015-03-31</date><risdate>2015</risdate><abstract>The present invention relates to 4-aryl-6-piperazin-1-yl-3-substituted-pyridazines that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, forexample schizophrenia, by exerting an antipsychotic effect without motor side effects.
La présente invention porte sur des 4-aryl-6-pipérazin-1-yl-pyridazines substituées en position 3, qui sont des antagonistes du récepteur de la dopamine 2 se dissociant rapidement, sur des procédés de préparation de ces composés, sur des compositions pharmaceutiques comprenant ces composés comme ingrédient actif. Les composés trouvent utilité comme médicaments pour traiter ou prévenir des troubles du système nerveux central, par exemple la schizophrénie, en exerçant un effet anti-psychotique sans effets secondaires moteurs.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | 3,4-DIHYDROPYRROLO[1,2-A]PYRAZIN-1-YL AMINES USEFUL AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS |
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