1,5-DIPHENYL-3-BENZYLAMINO-1,5-DIHYDROPYRROLIDIN-2-ONE AS CB1 RECEPTOR MODULATORS

Compounds and pharmaceutical compositions of Formula (I) by blockade of the CB1 receptors via an inverse agonism mechanism which are useful for reducing body weight in mammals, cognitive impairment associated with schizophrenia, mitigating treatment emergent weight gain observed during treatment wit...

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Hauptverfasser: SCHAUS, JOHN MEHNERT, KRUSHINSKI, JOSEPH HERMAN JUNIOR, TUPPER, DAVID EDWARD, KEDING, STACY JO, HU, JINGDAN, COFFEY, DAVID SCOTT
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creator SCHAUS, JOHN MEHNERT
KRUSHINSKI, JOSEPH HERMAN JUNIOR
TUPPER, DAVID EDWARD
KEDING, STACY JO
HU, JINGDAN
COFFEY, DAVID SCOTT
description Compounds and pharmaceutical compositions of Formula (I) by blockade of the CB1 receptors via an inverse agonism mechanism which are useful for reducing body weight in mammals, cognitive impairment associated with schizophrenia, mitigating treatment emergent weight gain observed during treatment with antipsychotics and have increased bioavailability.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title 1,5-DIPHENYL-3-BENZYLAMINO-1,5-DIHYDROPYRROLIDIN-2-ONE AS CB1 RECEPTOR MODULATORS
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