1,5-DIPHENYL-3-BENZYLAMINO-1,5-DIHYDROPYRROLIDIN-2-ONE AS CB1 RECEPTOR MODULATORS
Compounds and pharmaceutical compositions of Formula (I) by blockade of the CB1 receptors via an inverse agonism mechanism which are useful for reducing body weight in mammals, cognitive impairment associated with schizophrenia, mitigating treatment emergent weight gain observed during treatment wit...
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creator | SCHAUS, JOHN MEHNERT KRUSHINSKI, JOSEPH HERMAN JUNIOR TUPPER, DAVID EDWARD KEDING, STACY JO HU, JINGDAN COFFEY, DAVID SCOTT |
description | Compounds and pharmaceutical compositions of Formula (I) by blockade of the CB1 receptors via an inverse agonism mechanism which are useful for reducing body weight in mammals, cognitive impairment associated with schizophrenia, mitigating treatment emergent weight gain observed during treatment with antipsychotics and have increased bioavailability. |
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subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
title | 1,5-DIPHENYL-3-BENZYLAMINO-1,5-DIHYDROPYRROLIDIN-2-ONE AS CB1 RECEPTOR MODULATORS |
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