ANTI-COCAINE COMPOSITIONS AND TREATMENT

Embodiments of the invention disclosed herein generally relate to anti-cocaine therapeutics. Specifically, some embodiments of the invention relate to highly efficient, thermostable, and long-lasting cocaine esterase (CocE) mutants that can protect against the toxic and reinforcing effects of cocain...

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Hauptverfasser:	DENG, SHI-XIAN, ZHAN, CHANG-GUO, MACDONALD, JOANNE, GAO, DAQUAN, LEE, TIEN-YI, KO, MEIUAN HOLDEN, KWON, YOUNG MIN, WOODS, JAMES H, SUNAHARA, ROGER, YANG, VICTOR, TESMER, JOHN J, LANDRY, DONALD, NARASIMHAN, DIWAHAR L
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Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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creator	DENG, SHI-XIAN ZHAN, CHANG-GUO MACDONALD, JOANNE GAO, DAQUAN LEE, TIEN-YI KO, MEIUAN HOLDEN KWON, YOUNG MIN WOODS, JAMES H SUNAHARA, ROGER YANG, VICTOR TESMER, JOHN J LANDRY, DONALD NARASIMHAN, DIWAHAR L
description	Embodiments of the invention disclosed herein generally relate to anti-cocaine therapeutics. Specifically, some embodiments of the invention relate to highly efficient, thermostable, and long-lasting cocaine esterase (CocE) mutants that can protect against the toxic and reinforcing effects of cocaine in subjects. Provided herein are mutant CocE polypeptides displaying thermostable esterase activity. Also provided are methods of treating cocaine-induced conditions in a subject in need via administration of mutant CocE as well as methods for high-throughput screening of candidate esterase polypeptides. Les modes de réalisation de l'invention divulgués concernent généralement des traitements anti-cocaïne. Spécifiquement, certains modes de réalisation de l'invention concernent des mutants d'estérase de cocaïne longue durée, efficaces et thermostables (CocE), qui peuvent protéger contre les effets toxiques et renforçants de la cocaïne chez les sujets. Les polypeptides CoCE mutants qui sont décris affichent une activité d'estérase thermostable. L'invention concerne également des procédés de traitement des conditions induites par la cocaïne chez un sujet en ayant besoin, par administration de CoCE mutant, ainsi que des procédés pour une analyse à rendement élevé de polypeptides d'estérase candidats.
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Specifically, some embodiments of the invention relate to highly efficient, thermostable, and long-lasting cocaine esterase (CocE) mutants that can protect against the toxic and reinforcing effects of cocaine in subjects. Provided herein are mutant CocE polypeptides displaying thermostable esterase activity. Also provided are methods of treating cocaine-induced conditions in a subject in need via administration of mutant CocE as well as methods for high-throughput screening of candidate esterase polypeptides. Les modes de réalisation de l'invention divulgués concernent généralement des traitements anti-cocaïne. Spécifiquement, certains modes de réalisation de l'invention concernent des mutants d'estérase de cocaïne longue durée, efficaces et thermostables (CocE), qui peuvent protéger contre les effets toxiques et renforçants de la cocaïne chez les sujets. Les polypeptides CoCE mutants qui sont décris affichent une activité d'estérase thermostable. L'invention concerne également des procédés de traitement des conditions induites par la cocaïne chez un sujet en ayant besoin, par administration de CoCE mutant, ainsi que des procédés pour une analyse à rendement élevé de polypeptides d'estérase candidats.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20171031&DB=EPODOC&CC=CA&NR=2657246C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20171031&DB=EPODOC&CC=CA&NR=2657246C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>DENG, SHI-XIAN</creatorcontrib><creatorcontrib>ZHAN, CHANG-GUO</creatorcontrib><creatorcontrib>MACDONALD, JOANNE</creatorcontrib><creatorcontrib>GAO, DAQUAN</creatorcontrib><creatorcontrib>LEE, TIEN-YI</creatorcontrib><creatorcontrib>KO, MEIUAN HOLDEN</creatorcontrib><creatorcontrib>KWON, YOUNG MIN</creatorcontrib><creatorcontrib>WOODS, JAMES H</creatorcontrib><creatorcontrib>SUNAHARA, ROGER</creatorcontrib><creatorcontrib>YANG, VICTOR</creatorcontrib><creatorcontrib>TESMER, JOHN J</creatorcontrib><creatorcontrib>LANDRY, DONALD</creatorcontrib><creatorcontrib>NARASIMHAN, DIWAHAR L</creatorcontrib><title>ANTI-COCAINE COMPOSITIONS AND TREATMENT</title><description>Embodiments of the invention disclosed herein generally relate to anti-cocaine therapeutics. 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Specifically, some embodiments of the invention relate to highly efficient, thermostable, and long-lasting cocaine esterase (CocE) mutants that can protect against the toxic and reinforcing effects of cocaine in subjects. Provided herein are mutant CocE polypeptides displaying thermostable esterase activity. Also provided are methods of treating cocaine-induced conditions in a subject in need via administration of mutant CocE as well as methods for high-throughput screening of candidate esterase polypeptides. Les modes de réalisation de l'invention divulgués concernent généralement des traitements anti-cocaïne. Spécifiquement, certains modes de réalisation de l'invention concernent des mutants d'estérase de cocaïne longue durée, efficaces et thermostables (CocE), qui peuvent protéger contre les effets toxiques et renforçants de la cocaïne chez les sujets. Les polypeptides CoCE mutants qui sont décris affichent une activité d'estérase thermostable. L'invention concerne également des procédés de traitement des conditions induites par la cocaïne chez un sujet en ayant besoin, par administration de CoCE mutant, ainsi que des procédés pour une analyse à rendement élevé de polypeptides d'estérase candidats.</abstract><oa>free_for_read</oa></addata></record>
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subjects	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
title	ANTI-COCAINE COMPOSITIONS AND TREATMENT
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