PRODRUGS OF 5-AMINO-3-(3'-DEOXY-.BETA.-D-RIBOFURANOSYL)-THIAZOLO[4,5-D]PYRIMIDIN-2,7-DIONE
The invention relates to a compound of Formula I: (see formula I) or a pharmaceutically acceptable salt thereof, wherein: R1 is NH2 or -N=CH-NR6R7, R2 is H, OH, or -OR5, R3 is OH, -OC(O)C1-C18alkyl, -OCO2R5, -OC(O)NR6R7, or a racemic, L-, or D-amino acid group -OC(O)CHR8NHR9, R4 is OH, -OC(O)C1-C18a...
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| creator | HALEY, GREGORY J LENNOX, JOSEPH R XIANG, ALAN XIN WEBBER, STEPHEN E |
| description | The invention relates to a compound of Formula I: (see formula I) or a pharmaceutically acceptable salt thereof, wherein: R1 is NH2 or -N=CH-NR6R7, R2 is H, OH, or -OR5, R3 is OH, -OC(O)C1-C18alkyl, -OCO2R5, -OC(O)NR6R7, or a racemic, L-, or D-amino acid group -OC(O)CHR8NHR9, R4 is OH, -OC(O)C1-C18alkyl, -OCO2R5, -OC(O)NR6R7, or a racemic, L-, or D-amino acid group -OC(O)CHR8NHR9, R5 is -C1-C7alkyl, R6 and R7 are independently -C1-C7alkyl or together with nitrogen atom to which they are attached form a 5- or 6-membered heterocyclic ring, R8 is H or -C1-C7alkyl, R9 is H, -C1-C7alkyl, -C(O)R5, or -CO2R5, wherein at least one of R3 or R4 is -OCO2R5, -OC(O)NR6R7, or a racemic, L-, or D-amino acid group -OC(O)CHR8NHR9, and wherein the above alkyl is optionally substituted by 1-4 substituents. The invention also relates to the therapeutic use of such a compound and pharmaceutical compositions thereof for modulating immune cytokine activities and in treating disease states associated with abnormal cell growth, such as cancer. |
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The invention also relates to the therapeutic use of such a compound and pharmaceutical compositions thereof for modulating immune cytokine activities and in treating disease states associated with abnormal cell growth, such as cancer.</description><language>eng ; fre</language><subject>CHEMISTRY ; DERIVATIVES THEREOF ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SUGARS</subject><creationdate>2014</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20141118&DB=EPODOC&CC=CA&NR=2655904C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20141118&DB=EPODOC&CC=CA&NR=2655904C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HALEY, GREGORY J</creatorcontrib><creatorcontrib>LENNOX, JOSEPH R</creatorcontrib><creatorcontrib>XIANG, ALAN XIN</creatorcontrib><creatorcontrib>WEBBER, STEPHEN E</creatorcontrib><title>PRODRUGS OF 5-AMINO-3-(3'-DEOXY-.BETA.-D-RIBOFURANOSYL)-THIAZOLO[4,5-D]PYRIMIDIN-2,7-DIONE</title><description>The invention relates to a compound of Formula I: (see formula I) or a pharmaceutically acceptable salt thereof, wherein: R1 is NH2 or -N=CH-NR6R7, R2 is H, OH, or -OR5, R3 is OH, -OC(O)C1-C18alkyl, -OCO2R5, -OC(O)NR6R7, or a racemic, L-, or D-amino acid group -OC(O)CHR8NHR9, R4 is OH, -OC(O)C1-C18alkyl, -OCO2R5, -OC(O)NR6R7, or a racemic, L-, or D-amino acid group -OC(O)CHR8NHR9, R5 is -C1-C7alkyl, R6 and R7 are independently -C1-C7alkyl or together with nitrogen atom to which they are attached form a 5- or 6-membered heterocyclic ring, R8 is H or -C1-C7alkyl, R9 is H, -C1-C7alkyl, -C(O)R5, or -CO2R5, wherein at least one of R3 or R4 is -OCO2R5, -OC(O)NR6R7, or a racemic, L-, or D-amino acid group -OC(O)CHR8NHR9, and wherein the above alkyl is optionally substituted by 1-4 substituents. The invention also relates to the therapeutic use of such a compound and pharmaceutical compositions thereof for modulating immune cytokine activities and in treating disease states associated with abnormal cell growth, such as cancer.</description><subject>CHEMISTRY</subject><subject>DERIVATIVES THEREOF</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SUGARS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2014</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFykELgjAUAGAvHaL6DXmrwCehrug4t5kPdE-mQjNCJNYpSrD_T5funb7LN_e6ypA07bn2KfMZ8BI1QQzbeANS0cVCmKqGhyDBYEpZa7im2hY7aHLkHRV0TQIG8lZZgyVK1BAFR5BIWi292WN4Tm71c-GtM9WIHNz47t00Dnf3cp9e8OjA2GmfiPj_-AIX1zAO</recordid><startdate>20141118</startdate><enddate>20141118</enddate><creator>HALEY, GREGORY J</creator><creator>LENNOX, JOSEPH R</creator><creator>XIANG, ALAN XIN</creator><creator>WEBBER, STEPHEN E</creator><scope>EVB</scope></search><sort><creationdate>20141118</creationdate><title>PRODRUGS OF 5-AMINO-3-(3'-DEOXY-.BETA.-D-RIBOFURANOSYL)-THIAZOLO[4,5-D]PYRIMIDIN-2,7-DIONE</title><author>HALEY, GREGORY J ; LENNOX, JOSEPH R ; XIANG, ALAN XIN ; WEBBER, STEPHEN E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2655904C3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2014</creationdate><topic>CHEMISTRY</topic><topic>DERIVATIVES THEREOF</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SUGARS</topic><toplevel>online_resources</toplevel><creatorcontrib>HALEY, GREGORY J</creatorcontrib><creatorcontrib>LENNOX, JOSEPH R</creatorcontrib><creatorcontrib>XIANG, ALAN XIN</creatorcontrib><creatorcontrib>WEBBER, STEPHEN E</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HALEY, GREGORY J</au><au>LENNOX, JOSEPH R</au><au>XIANG, ALAN XIN</au><au>WEBBER, STEPHEN E</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PRODRUGS OF 5-AMINO-3-(3'-DEOXY-.BETA.-D-RIBOFURANOSYL)-THIAZOLO[4,5-D]PYRIMIDIN-2,7-DIONE</title><date>2014-11-18</date><risdate>2014</risdate><abstract>The invention relates to a compound of Formula I: (see formula I) or a pharmaceutically acceptable salt thereof, wherein: R1 is NH2 or -N=CH-NR6R7, R2 is H, OH, or -OR5, R3 is OH, -OC(O)C1-C18alkyl, -OCO2R5, -OC(O)NR6R7, or a racemic, L-, or D-amino acid group -OC(O)CHR8NHR9, R4 is OH, -OC(O)C1-C18alkyl, -OCO2R5, -OC(O)NR6R7, or a racemic, L-, or D-amino acid group -OC(O)CHR8NHR9, R5 is -C1-C7alkyl, R6 and R7 are independently -C1-C7alkyl or together with nitrogen atom to which they are attached form a 5- or 6-membered heterocyclic ring, R8 is H or -C1-C7alkyl, R9 is H, -C1-C7alkyl, -C(O)R5, or -CO2R5, wherein at least one of R3 or R4 is -OCO2R5, -OC(O)NR6R7, or a racemic, L-, or D-amino acid group -OC(O)CHR8NHR9, and wherein the above alkyl is optionally substituted by 1-4 substituents. The invention also relates to the therapeutic use of such a compound and pharmaceutical compositions thereof for modulating immune cytokine activities and in treating disease states associated with abnormal cell growth, such as cancer.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS |
| title | PRODRUGS OF 5-AMINO-3-(3'-DEOXY-.BETA.-D-RIBOFURANOSYL)-THIAZOLO[4,5-D]PYRIMIDIN-2,7-DIONE |
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