DEMETHYLATION OF 14-HYDROXY SUBSTITUTED ALKALOID DERIVATIVES

DEMETHYLATION OF 14-HYDROXY SUBSTITUTED ALKALOID DERIVATIVES

The present invention is directed to a method for demethylating 14-hydroxy substituted alkaloid derivatives, in particular of 14-hydroxy-17-methyl-4,5- epoxymorphinane-6-on--derivatives. This is achieved by reacting a starting compound with a compound of general formula R1OOC-N=N-COOR2 in a suitable...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: BERTOGG, ANDREAS, DINKEL, THOMAS, LAUTERBACH, ERIK HEINZ, HELLER, SABRINA
Format: Patent
Sprache:eng ; fre
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention is directed to a method for demethylating 14-hydroxy substituted alkaloid derivatives, in particular of 14-hydroxy-17-methyl-4,5- epoxymorphinane-6-on--derivatives. This is achieved by reacting a starting compound with a compound of general formula R1OOC-N=N-COOR2 in a suitable solvent. La présente invention est axée sur une méthode pour déméthyler des dérivés alcaloïdes substitués par 14-hydroxyle, en particulier les dérivés 14-hydroxyle-17-méthyle-4,5- époxymorphinane-6-on. On y parvient en faisant réagir un composé de départ avec un composé de formule générale R1OOC-N=N-COOR2 dans un solvant acceptable.