COMPOSITIONS AND METHODS FOR PRODUCING A COMPOSITION

The invention provides for mammalian cells capable of producing recombinant CTLA4-Ig and variants thereof. The invention also provides for compositions comprising CTLA4-Ig and formulations thereof. The invention further provides for methods for mass- producing CTLA4-Ig from mammalian cells capable o...

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Bibliographische Detailangaben
Hauptverfasser:	TAY, LEE K, FLESHER, ALAN R, KIRKLEY, DAVID H, LEISTER, KIRK J, SCHAEFER, EUGENE J, RUSSELL, REB J, TABOR, JOHN M, BROWNELL, DEAN, SCHRIMSHER, JEFFREY, THAMMANA, PALLAIAH, VELAYUDHAN, AJOY, VANDEN BOOM, THOMAS, DONALDSON, ROBERT, BRAMHALL, ELIZABETH A, SMOLIN, DAVID E, BATES, RONALD, DIDIO, DAVID M, WHITEHEAD, JOYCE, HAGGERTY, HELEN G
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The invention provides for mammalian cells capable of producing recombinant CTLA4-Ig and variants thereof. The invention also provides for compositions comprising CTLA4-Ig and formulations thereof. The invention further provides for methods for mass- producing CTLA4-Ig from mammalian cells capable of producing this recombinant protein, and for purifying the CTLA4-Ig. L'invention concerne des cellules de mammifères capables de produire du CTLA4-Ig recombinant et des variants de celui-ci. L'invention concerne également des compositions comprenant du CTLA4-Ig et leurs formulations. L'invention concerne en outre des procédés de production en gros volume de CTLA4-Ig à partir de cellules de mammifères capables de produire cette protéine recombinante, ainsi que des procédés de purification du CTLA4-Ig.