2,4,5-TRIPHENYL IMIDAZOLINE DERIVATIVES AS INHIBITORS OF THE INTERACTION BETWEEN P53 AND MDM2 PROTEINS FOR USE AS ANTICANCER AGENTS
There is provided a compound of formula (I) and the pharmaceutically acceptable salts and esters thereof wherein X1 , X2, R1 , R2, R3, R4, R5 and R6 are herein described. The compounds exhibit activity as anticancer agents. la présente invention concerne un composé répondant à la formule (I) ainsi q...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; fre |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | LIU, JIN-JUN LOVEY, ALLEN JOHN KONG, NORMAN PIZZOLATO, GIACOMO GRAVES, BRADFORD JAMES WOVKULICH, PETER MICHAEL SO, SUNG-SAU ROBERTS, JOHN LAWSON VU, BINH THANH DING, QINGJIE |
| description | There is provided a compound of formula (I) and the pharmaceutically acceptable salts and esters thereof wherein X1 , X2, R1 , R2, R3, R4, R5 and R6 are herein described. The compounds exhibit activity as anticancer agents.
la présente invention concerne un composé répondant à la formule (I) ainsi que des sels et esters pharmaceutiquement acceptables de celui-ci, X1 , X2, R1 , R2, R3, R4, R5 et R6 étant tels que décrits dans le présent document. Lesdits composés sont actifs en tant qu'agents anticancéreux. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CA2630410C</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CA2630410C</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CA2630410C3</originalsourceid><addsrcrecordid>eNqFjDEKwkAQANNYiPoG9wEGYmLsN5eNWTB74W5VtAlBzko0oD_w4yrYWw0Mw4yjV7pYLfJYHbc1yXEL3HCJJ7tlISjJ8R6V9-QBPbDUXLBa58FWoDV9jJJDo2wFCtIDkUCbZ4BSQlM2KbTOKrF4qKyDnafvBkXZoBhygBsS9dNodOmvjzD7cRLNK1JTx2G4d-Ex9OdwC8_OYLrOktUyMdn_4g3FwDtK</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>2,4,5-TRIPHENYL IMIDAZOLINE DERIVATIVES AS INHIBITORS OF THE INTERACTION BETWEEN P53 AND MDM2 PROTEINS FOR USE AS ANTICANCER AGENTS</title><source>esp@cenet</source><creator>LIU, JIN-JUN ; LOVEY, ALLEN JOHN ; KONG, NORMAN ; PIZZOLATO, GIACOMO ; GRAVES, BRADFORD JAMES ; WOVKULICH, PETER MICHAEL ; SO, SUNG-SAU ; ROBERTS, JOHN LAWSON ; VU, BINH THANH ; DING, QINGJIE</creator><creatorcontrib>LIU, JIN-JUN ; LOVEY, ALLEN JOHN ; KONG, NORMAN ; PIZZOLATO, GIACOMO ; GRAVES, BRADFORD JAMES ; WOVKULICH, PETER MICHAEL ; SO, SUNG-SAU ; ROBERTS, JOHN LAWSON ; VU, BINH THANH ; DING, QINGJIE</creatorcontrib><description>There is provided a compound of formula (I) and the pharmaceutically acceptable salts and esters thereof wherein X1 , X2, R1 , R2, R3, R4, R5 and R6 are herein described. The compounds exhibit activity as anticancer agents.
la présente invention concerne un composé répondant à la formule (I) ainsi que des sels et esters pharmaceutiquement acceptables de celui-ci, X1 , X2, R1 , R2, R3, R4, R5 et R6 étant tels que décrits dans le présent document. Lesdits composés sont actifs en tant qu'agents anticancéreux.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2014</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20140225&DB=EPODOC&CC=CA&NR=2630410C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20140225&DB=EPODOC&CC=CA&NR=2630410C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LIU, JIN-JUN</creatorcontrib><creatorcontrib>LOVEY, ALLEN JOHN</creatorcontrib><creatorcontrib>KONG, NORMAN</creatorcontrib><creatorcontrib>PIZZOLATO, GIACOMO</creatorcontrib><creatorcontrib>GRAVES, BRADFORD JAMES</creatorcontrib><creatorcontrib>WOVKULICH, PETER MICHAEL</creatorcontrib><creatorcontrib>SO, SUNG-SAU</creatorcontrib><creatorcontrib>ROBERTS, JOHN LAWSON</creatorcontrib><creatorcontrib>VU, BINH THANH</creatorcontrib><creatorcontrib>DING, QINGJIE</creatorcontrib><title>2,4,5-TRIPHENYL IMIDAZOLINE DERIVATIVES AS INHIBITORS OF THE INTERACTION BETWEEN P53 AND MDM2 PROTEINS FOR USE AS ANTICANCER AGENTS</title><description>There is provided a compound of formula (I) and the pharmaceutically acceptable salts and esters thereof wherein X1 , X2, R1 , R2, R3, R4, R5 and R6 are herein described. The compounds exhibit activity as anticancer agents.
la présente invention concerne un composé répondant à la formule (I) ainsi que des sels et esters pharmaceutiquement acceptables de celui-ci, X1 , X2, R1 , R2, R3, R4, R5 et R6 étant tels que décrits dans le présent document. Lesdits composés sont actifs en tant qu'agents anticancéreux.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2014</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFjDEKwkAQANNYiPoG9wEGYmLsN5eNWTB74W5VtAlBzko0oD_w4yrYWw0Mw4yjV7pYLfJYHbc1yXEL3HCJJ7tlISjJ8R6V9-QBPbDUXLBa58FWoDV9jJJDo2wFCtIDkUCbZ4BSQlM2KbTOKrF4qKyDnafvBkXZoBhygBsS9dNodOmvjzD7cRLNK1JTx2G4d-Ex9OdwC8_OYLrOktUyMdn_4g3FwDtK</recordid><startdate>20140225</startdate><enddate>20140225</enddate><creator>LIU, JIN-JUN</creator><creator>LOVEY, ALLEN JOHN</creator><creator>KONG, NORMAN</creator><creator>PIZZOLATO, GIACOMO</creator><creator>GRAVES, BRADFORD JAMES</creator><creator>WOVKULICH, PETER MICHAEL</creator><creator>SO, SUNG-SAU</creator><creator>ROBERTS, JOHN LAWSON</creator><creator>VU, BINH THANH</creator><creator>DING, QINGJIE</creator><scope>EVB</scope></search><sort><creationdate>20140225</creationdate><title>2,4,5-TRIPHENYL IMIDAZOLINE DERIVATIVES AS INHIBITORS OF THE INTERACTION BETWEEN P53 AND MDM2 PROTEINS FOR USE AS ANTICANCER AGENTS</title><author>LIU, JIN-JUN ; LOVEY, ALLEN JOHN ; KONG, NORMAN ; PIZZOLATO, GIACOMO ; GRAVES, BRADFORD JAMES ; WOVKULICH, PETER MICHAEL ; SO, SUNG-SAU ; ROBERTS, JOHN LAWSON ; VU, BINH THANH ; DING, QINGJIE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2630410C3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2014</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>LIU, JIN-JUN</creatorcontrib><creatorcontrib>LOVEY, ALLEN JOHN</creatorcontrib><creatorcontrib>KONG, NORMAN</creatorcontrib><creatorcontrib>PIZZOLATO, GIACOMO</creatorcontrib><creatorcontrib>GRAVES, BRADFORD JAMES</creatorcontrib><creatorcontrib>WOVKULICH, PETER MICHAEL</creatorcontrib><creatorcontrib>SO, SUNG-SAU</creatorcontrib><creatorcontrib>ROBERTS, JOHN LAWSON</creatorcontrib><creatorcontrib>VU, BINH THANH</creatorcontrib><creatorcontrib>DING, QINGJIE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LIU, JIN-JUN</au><au>LOVEY, ALLEN JOHN</au><au>KONG, NORMAN</au><au>PIZZOLATO, GIACOMO</au><au>GRAVES, BRADFORD JAMES</au><au>WOVKULICH, PETER MICHAEL</au><au>SO, SUNG-SAU</au><au>ROBERTS, JOHN LAWSON</au><au>VU, BINH THANH</au><au>DING, QINGJIE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>2,4,5-TRIPHENYL IMIDAZOLINE DERIVATIVES AS INHIBITORS OF THE INTERACTION BETWEEN P53 AND MDM2 PROTEINS FOR USE AS ANTICANCER AGENTS</title><date>2014-02-25</date><risdate>2014</risdate><abstract>There is provided a compound of formula (I) and the pharmaceutically acceptable salts and esters thereof wherein X1 , X2, R1 , R2, R3, R4, R5 and R6 are herein described. The compounds exhibit activity as anticancer agents.
la présente invention concerne un composé répondant à la formule (I) ainsi que des sels et esters pharmaceutiquement acceptables de celui-ci, X1 , X2, R1 , R2, R3, R4, R5 et R6 étant tels que décrits dans le présent document. Lesdits composés sont actifs en tant qu'agents anticancéreux.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; fre |
| recordid | cdi_epo_espacenet_CA2630410C |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | 2,4,5-TRIPHENYL IMIDAZOLINE DERIVATIVES AS INHIBITORS OF THE INTERACTION BETWEEN P53 AND MDM2 PROTEINS FOR USE AS ANTICANCER AGENTS |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T07%3A08%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=LIU,%20JIN-JUN&rft.date=2014-02-25&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECA2630410C%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |