USE OF MAS G-PROTEIN-COUPLED RECEPTOR AGONISTS AND ANTAGONISTS AS APOPTOTIC ACTIVITY MODULATORS FOR PREVENTION AND TREATMENT OF DISEASES
The present invention is characterized by the use of Mas G- protein-coupled receptor agonists and antagonists as apoptotic activity modulators for study , prevention and treatment of diseases. It is further characterized by the use of Mas G-protein-coupled receptor agonist and antagonists for modula...
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| creator | SOUZA DOS SANTOS, ROBSON AUGUSTO DE FARIA E SILVA, RAPHAEL DE OLIVEIRA SAMPAIO, WALKYRIA NEYDE DE CASTRO LEAL, MARCELO DOS REIS, ADELINA MARTHA BARROS DE SOUSA, FREDERICO FREZARD, FREDERIC JEAN GEORGES KAPPES BECKER, LENICE DE FRANCA, LUIZ RENATO FERREIRA, ANDERSON JOSE SINISTERRA, RUBEN DARIO SILVA LULA, IVANA VELOSO BRANT PINHEIRO, SERGIO CAMPAGNOLE-SANTOS, MARIA JOSE |
| description | The present invention is characterized by the use of Mas G- protein-coupled receptor agonists and antagonists as apoptotic activity modulators for study , prevention and treatment of diseases. It is further characterized by the use of Mas G-protein-coupled receptor agonist and antagonists for modulation of the apoptotic activity involving alterations in the activity of the protein kinase B/Akt. Another characteristic of the invention is the use of Mas G- protein-coupled receptor agonists and antagonists, including the Ang- (1-7) peptide and its analogues, agonists and antagonists, either peptidic or non- peptidic, as modulators of apoptotic activity for study, prevention and treatment of degenerative diseases of organs and systems, as an auxiliary measure for organs transplantation, treatment with embryonic, non- embryonic stem cells, re-implantation of organs and tissues and other treatments that need temporary or chronic reduction of the apoptotic activity, not limitativ e. The invention further claims the use of Mas G-protein-coupled receptor agonists and antagonists, including the Angiotensin-(1-7) peptide and its analogues, agonists and antagonists, either peptidic or non-peptidic, formulated with pharmaceutically and pharmacologically acceptable excipients or carriers, as modulators of the apoptotic activity. |
| format | Patent |
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It is further characterized by the use of Mas G-protein-coupled receptor agonist and antagonists for modulation of the apoptotic activity involving alterations in the activity of the protein kinase B/Akt. Another characteristic of the invention is the use of Mas G- protein-coupled receptor agonists and antagonists, including the Ang- (1-7) peptide and its analogues, agonists and antagonists, either peptidic or non- peptidic, as modulators of apoptotic activity for study, prevention and treatment of degenerative diseases of organs and systems, as an auxiliary measure for organs transplantation, treatment with embryonic, non- embryonic stem cells, re-implantation of organs and tissues and other treatments that need temporary or chronic reduction of the apoptotic activity, not limitativ e. The invention further claims the use of Mas G-protein-coupled receptor agonists and antagonists, including the Angiotensin-(1-7) peptide and its analogues, agonists and antagonists, either peptidic or non-peptidic, formulated with pharmaceutically and pharmacologically acceptable excipients or carriers, as modulators of the apoptotic activity.</description><language>eng ; fre</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2007</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20070104&DB=EPODOC&CC=CA&NR=2613126A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20070104&DB=EPODOC&CC=CA&NR=2613126A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SOUZA DOS SANTOS, ROBSON AUGUSTO</creatorcontrib><creatorcontrib>DE FARIA E SILVA, RAPHAEL</creatorcontrib><creatorcontrib>DE OLIVEIRA SAMPAIO, WALKYRIA NEYDE</creatorcontrib><creatorcontrib>DE CASTRO LEAL, MARCELO</creatorcontrib><creatorcontrib>DOS REIS, ADELINA MARTHA</creatorcontrib><creatorcontrib>BARROS DE SOUSA, FREDERICO</creatorcontrib><creatorcontrib>FREZARD, FREDERIC JEAN GEORGES</creatorcontrib><creatorcontrib>KAPPES BECKER, LENICE</creatorcontrib><creatorcontrib>DE FRANCA, LUIZ RENATO</creatorcontrib><creatorcontrib>FERREIRA, ANDERSON JOSE</creatorcontrib><creatorcontrib>SINISTERRA, RUBEN DARIO</creatorcontrib><creatorcontrib>SILVA LULA, IVANA</creatorcontrib><creatorcontrib>VELOSO BRANT PINHEIRO, SERGIO</creatorcontrib><creatorcontrib>CAMPAGNOLE-SANTOS, MARIA JOSE</creatorcontrib><title>USE OF MAS G-PROTEIN-COUPLED RECEPTOR AGONISTS AND ANTAGONISTS AS APOPTOTIC ACTIVITY MODULATORS FOR PREVENTION AND TREATMENT OF DISEASES</title><description>The present invention is characterized by the use of Mas G- protein-coupled receptor agonists and antagonists as apoptotic activity modulators for study , prevention and treatment of diseases. It is further characterized by the use of Mas G-protein-coupled receptor agonist and antagonists for modulation of the apoptotic activity involving alterations in the activity of the protein kinase B/Akt. Another characteristic of the invention is the use of Mas G- protein-coupled receptor agonists and antagonists, including the Ang- (1-7) peptide and its analogues, agonists and antagonists, either peptidic or non- peptidic, as modulators of apoptotic activity for study, prevention and treatment of degenerative diseases of organs and systems, as an auxiliary measure for organs transplantation, treatment with embryonic, non- embryonic stem cells, re-implantation of organs and tissues and other treatments that need temporary or chronic reduction of the apoptotic activity, not limitativ e. The invention further claims the use of Mas G-protein-coupled receptor agonists and antagonists, including the Angiotensin-(1-7) peptide and its analogues, agonists and antagonists, either peptidic or non-peptidic, formulated with pharmaceutically and pharmacologically acceptable excipients or carriers, as modulators of the apoptotic activity.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2007</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjcEKwjAMhnfxIOo75AV22Aa7hzabha0pbTbwNIbUk-hgPoSPbRXBq5AQ_p_vI9vsOQQCbqDHAG3uPAsZmyseXEcaPClywh6wZWuCBECr08ovp3GcGDEKUIkZjZygZz10mMQATbKdp5GsGLYfXzyh9Kl4P9YmEAYK-2xzma9rPHzvLoOGRB3zuNynuC7zOd7iY1JY1kVVlDUW1R_ICwu9PjY</recordid><startdate>20070104</startdate><enddate>20070104</enddate><creator>SOUZA DOS SANTOS, ROBSON AUGUSTO</creator><creator>DE FARIA E SILVA, RAPHAEL</creator><creator>DE OLIVEIRA SAMPAIO, WALKYRIA NEYDE</creator><creator>DE CASTRO LEAL, MARCELO</creator><creator>DOS REIS, ADELINA MARTHA</creator><creator>BARROS DE SOUSA, FREDERICO</creator><creator>FREZARD, FREDERIC JEAN GEORGES</creator><creator>KAPPES BECKER, LENICE</creator><creator>DE FRANCA, LUIZ RENATO</creator><creator>FERREIRA, ANDERSON JOSE</creator><creator>SINISTERRA, RUBEN DARIO</creator><creator>SILVA LULA, IVANA</creator><creator>VELOSO BRANT PINHEIRO, SERGIO</creator><creator>CAMPAGNOLE-SANTOS, MARIA JOSE</creator><scope>EVB</scope></search><sort><creationdate>20070104</creationdate><title>USE OF MAS G-PROTEIN-COUPLED RECEPTOR AGONISTS AND ANTAGONISTS AS APOPTOTIC ACTIVITY MODULATORS FOR PREVENTION AND TREATMENT OF DISEASES</title><author>SOUZA DOS SANTOS, ROBSON AUGUSTO ; DE FARIA E SILVA, RAPHAEL ; DE OLIVEIRA SAMPAIO, WALKYRIA NEYDE ; DE CASTRO LEAL, MARCELO ; DOS REIS, ADELINA MARTHA ; BARROS DE SOUSA, FREDERICO ; FREZARD, FREDERIC JEAN GEORGES ; KAPPES BECKER, LENICE ; DE FRANCA, LUIZ RENATO ; FERREIRA, ANDERSON JOSE ; SINISTERRA, RUBEN DARIO ; SILVA LULA, IVANA ; VELOSO BRANT PINHEIRO, SERGIO ; CAMPAGNOLE-SANTOS, MARIA JOSE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2613126A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2007</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>SOUZA DOS SANTOS, ROBSON AUGUSTO</creatorcontrib><creatorcontrib>DE FARIA E SILVA, RAPHAEL</creatorcontrib><creatorcontrib>DE OLIVEIRA SAMPAIO, WALKYRIA NEYDE</creatorcontrib><creatorcontrib>DE CASTRO LEAL, MARCELO</creatorcontrib><creatorcontrib>DOS REIS, ADELINA MARTHA</creatorcontrib><creatorcontrib>BARROS DE SOUSA, FREDERICO</creatorcontrib><creatorcontrib>FREZARD, FREDERIC JEAN GEORGES</creatorcontrib><creatorcontrib>KAPPES BECKER, LENICE</creatorcontrib><creatorcontrib>DE FRANCA, LUIZ RENATO</creatorcontrib><creatorcontrib>FERREIRA, ANDERSON JOSE</creatorcontrib><creatorcontrib>SINISTERRA, RUBEN DARIO</creatorcontrib><creatorcontrib>SILVA LULA, IVANA</creatorcontrib><creatorcontrib>VELOSO BRANT PINHEIRO, SERGIO</creatorcontrib><creatorcontrib>CAMPAGNOLE-SANTOS, MARIA JOSE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SOUZA DOS SANTOS, ROBSON AUGUSTO</au><au>DE FARIA E SILVA, RAPHAEL</au><au>DE OLIVEIRA SAMPAIO, WALKYRIA NEYDE</au><au>DE CASTRO LEAL, MARCELO</au><au>DOS REIS, ADELINA MARTHA</au><au>BARROS DE SOUSA, FREDERICO</au><au>FREZARD, FREDERIC JEAN GEORGES</au><au>KAPPES BECKER, LENICE</au><au>DE FRANCA, LUIZ RENATO</au><au>FERREIRA, ANDERSON JOSE</au><au>SINISTERRA, RUBEN DARIO</au><au>SILVA LULA, IVANA</au><au>VELOSO BRANT PINHEIRO, SERGIO</au><au>CAMPAGNOLE-SANTOS, MARIA JOSE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>USE OF MAS G-PROTEIN-COUPLED RECEPTOR AGONISTS AND ANTAGONISTS AS APOPTOTIC ACTIVITY MODULATORS FOR PREVENTION AND TREATMENT OF DISEASES</title><date>2007-01-04</date><risdate>2007</risdate><abstract>The present invention is characterized by the use of Mas G- protein-coupled receptor agonists and antagonists as apoptotic activity modulators for study , prevention and treatment of diseases. It is further characterized by the use of Mas G-protein-coupled receptor agonist and antagonists for modulation of the apoptotic activity involving alterations in the activity of the protein kinase B/Akt. Another characteristic of the invention is the use of Mas G- protein-coupled receptor agonists and antagonists, including the Ang- (1-7) peptide and its analogues, agonists and antagonists, either peptidic or non- peptidic, as modulators of apoptotic activity for study, prevention and treatment of degenerative diseases of organs and systems, as an auxiliary measure for organs transplantation, treatment with embryonic, non- embryonic stem cells, re-implantation of organs and tissues and other treatments that need temporary or chronic reduction of the apoptotic activity, not limitativ e. The invention further claims the use of Mas G-protein-coupled receptor agonists and antagonists, including the Angiotensin-(1-7) peptide and its analogues, agonists and antagonists, either peptidic or non-peptidic, formulated with pharmaceutically and pharmacologically acceptable excipients or carriers, as modulators of the apoptotic activity.</abstract><oa>free_for_read</oa></addata></record> |
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| title | USE OF MAS G-PROTEIN-COUPLED RECEPTOR AGONISTS AND ANTAGONISTS AS APOPTOTIC ACTIVITY MODULATORS FOR PREVENTION AND TREATMENT OF DISEASES |
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