STABLE AND SELECTIVE FORMATION OF HOOGSTEEN-TYPE TRIPLEXES AND DUPLEXES USING TWISTED INTERCALATING NUCLEIC ACIDS (TINA) AND PROCESS FOR THE PREPARATION OF TINA

The present invention describes a flexible basestacking monomer that can be incorporated into an oligonucleotide or oligonucleotide analogue, as well as triplex forming oligonucleotides comprising the flexible basestacking monomer. Triplex forming oligonucleotides of the invention are capable of bin...

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Bibliographische Detailangaben
Hauptverfasser: PEDERSEN, ERIK BJERREGAARD, FILICHEV, VYACHELSAV V
Format: Patent
Sprache:eng ; fre
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