PYRROLIDINE DERIVATIVE OR SALT THEREOF
[Problem] To provide a compound which may be used in treating diseases in which a calcium sensing receptor (CaSR) is concerned, particularly hyperparathyroidism. [Means for Resolution] It was found that novel pyrrolidine derivatives which are characterized by the possession of aminomethyl group subs...
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| creator | TERADA, YOH KAMIKUBO, TAKASHI SANAGI, MASANAO TAKAHASHI, TAISUKE HACHIYA, SHUNICHIRO SEO, RYUSHI MUKAI, HANA MATSUURA, KEISUKE YOSHIHARA, KOUSEI OKU, MAKOTO SHIN, TAKASHI |
| description | [Problem] To provide a compound which may be used in treating diseases in which a calcium sensing receptor (CaSR) is concerned, particularly hyperparathyroidism. [Means for Resolution] It was found that novel pyrrolidine derivatives which are characterized by the possession of aminomethyl group substituted with arylalkyl group or the like, or salts thereof, have excellent CaSR agonistic regulatory activity and also have excellent selectivity with CYP2D6 inhibitory activity having a possibility of causing drug interaction. Based on the above, these novel pyrrolidine derivatives are useful as therapeutic agents for treating diseases in which CaSR is concerned (hyperparathyroidism, renal osteodystrophy, hypercalcemia and the like). |
| format | Patent |
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[Means for Resolution] It was found that novel pyrrolidine derivatives which are characterized by the possession of aminomethyl group substituted with arylalkyl group or the like, or salts thereof, have excellent CaSR agonistic regulatory activity and also have excellent selectivity with CYP2D6 inhibitory activity having a possibility of causing drug interaction. Based on the above, these novel pyrrolidine derivatives are useful as therapeutic agents for treating diseases in which CaSR is concerned (hyperparathyroidism, renal osteodystrophy, hypercalcemia and the like).</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2006</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20061123&DB=EPODOC&CC=CA&NR=2608957A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20061123&DB=EPODOC&CC=CA&NR=2608957A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>TERADA, YOH</creatorcontrib><creatorcontrib>KAMIKUBO, TAKASHI</creatorcontrib><creatorcontrib>SANAGI, MASANAO</creatorcontrib><creatorcontrib>TAKAHASHI, TAISUKE</creatorcontrib><creatorcontrib>HACHIYA, SHUNICHIRO</creatorcontrib><creatorcontrib>SEO, RYUSHI</creatorcontrib><creatorcontrib>MUKAI, HANA</creatorcontrib><creatorcontrib>MATSUURA, KEISUKE</creatorcontrib><creatorcontrib>YOSHIHARA, KOUSEI</creatorcontrib><creatorcontrib>OKU, MAKOTO</creatorcontrib><creatorcontrib>SHIN, TAKASHI</creatorcontrib><title>PYRROLIDINE DERIVATIVE OR SALT THEREOF</title><description>[Problem] To provide a compound which may be used in treating diseases in which a calcium sensing receptor (CaSR) is concerned, particularly hyperparathyroidism. 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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | PYRROLIDINE DERIVATIVE OR SALT THEREOF |
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