NOVEL SUBSTITUTED TETRACYCLIC TETRAHYDROFURAN, PYRROLIDINE AND TETRAHYDROTHIOPHENE DERIVATIVES AND THEIR USE AS A MEDICAMENT
This invention concerns novel substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives with binding affinities towards serotonin receptors, in particular 5-HT2A and 5-HT2C receptors, and towards dopamine receptors, in particular dopamine D2 receptors and with norepine...
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| creator | MAO, HUA JHA, SUSHIL CHANDRA COMPERNOLLE, FRANS JOSEF CORNELIUS MEGENS, ANTONIUS ADRIANUS HENDRIKUS PETRUS KOZLECKI, TOMASZ HOORNAERT, GEORGES JOSEPH CORNELIUS TRABANCO-SUAREZ, ANDRES AVELINO KOUKNI, MOHAMED FERNANDEZ-GADEA, FRANCISCO JAVIER CID-NUNEZ, JOSE MARIA |
| description | This invention concerns novel substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives with binding affinities towards serotonin receptors, in particular 5-HT2A and 5-HT2C receptors, and towards dopamine receptors, in particular dopamine D2 receptors and with norepinephrine reuptake inhibition properties, pharmaceutical compositions comprising the compounds according to the invention, the use thereof as a medicine, in particular for the prevention and/or treatment of a range of psychiatric and neurological disorders, in particular certain psychotic, cardiovascular and gastrokinetic disorders and processes for their productio n. The compounds according to the invention can be represented by general Formu la (I), and comprises also the pharmaceutically acceptable acid or base additio n salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in Cla im 1. |
| format | Patent |
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The compounds according to the invention can be represented by general Formu la (I), and comprises also the pharmaceutically acceptable acid or base additio n salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in Cla im 1.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2006</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20061130&DB=EPODOC&CC=CA&NR=2604165A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20061130&DB=EPODOC&CC=CA&NR=2604165A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MAO, HUA</creatorcontrib><creatorcontrib>JHA, SUSHIL CHANDRA</creatorcontrib><creatorcontrib>COMPERNOLLE, FRANS JOSEF CORNELIUS</creatorcontrib><creatorcontrib>MEGENS, ANTONIUS ADRIANUS HENDRIKUS PETRUS</creatorcontrib><creatorcontrib>KOZLECKI, TOMASZ</creatorcontrib><creatorcontrib>HOORNAERT, GEORGES JOSEPH CORNELIUS</creatorcontrib><creatorcontrib>TRABANCO-SUAREZ, ANDRES AVELINO</creatorcontrib><creatorcontrib>KOUKNI, MOHAMED</creatorcontrib><creatorcontrib>FERNANDEZ-GADEA, FRANCISCO JAVIER</creatorcontrib><creatorcontrib>CID-NUNEZ, JOSE MARIA</creatorcontrib><title>NOVEL SUBSTITUTED TETRACYCLIC TETRAHYDROFURAN, PYRROLIDINE AND TETRAHYDROTHIOPHENE DERIVATIVES AND THEIR USE AS A MEDICAMENT</title><description>This invention concerns novel substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives with binding affinities towards serotonin receptors, in particular 5-HT2A and 5-HT2C receptors, and towards dopamine receptors, in particular dopamine D2 receptors and with norepinephrine reuptake inhibition properties, pharmaceutical compositions comprising the compounds according to the invention, the use thereof as a medicine, in particular for the prevention and/or treatment of a range of psychiatric and neurological disorders, in particular certain psychotic, cardiovascular and gastrokinetic disorders and processes for their productio n. The compounds according to the invention can be represented by general Formu la (I), and comprises also the pharmaceutically acceptable acid or base additio n salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in Cla im 1.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2006</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNi70KwjAURrs4iPoO9wEUrD_dY3JLLrRJSW4CnUqROIkW6ujDW6iDo9N3OJxvmb2NjViBDxfPxIFRASM7IVtZkZxZt8rZMjhhttC0ztmKFBkEYdRPwJpso3HyCh1FwRTRz41GchD89JgE1KhIihoNr7PFrb-PafPdVQYlstS7NDy7NA79NT3Sq5PiUOxPeXEW-fGP5AObcDs-</recordid><startdate>20061130</startdate><enddate>20061130</enddate><creator>MAO, HUA</creator><creator>JHA, SUSHIL CHANDRA</creator><creator>COMPERNOLLE, FRANS JOSEF CORNELIUS</creator><creator>MEGENS, ANTONIUS ADRIANUS HENDRIKUS PETRUS</creator><creator>KOZLECKI, TOMASZ</creator><creator>HOORNAERT, GEORGES JOSEPH CORNELIUS</creator><creator>TRABANCO-SUAREZ, ANDRES AVELINO</creator><creator>KOUKNI, MOHAMED</creator><creator>FERNANDEZ-GADEA, FRANCISCO JAVIER</creator><creator>CID-NUNEZ, JOSE MARIA</creator><scope>EVB</scope></search><sort><creationdate>20061130</creationdate><title>NOVEL SUBSTITUTED TETRACYCLIC TETRAHYDROFURAN, PYRROLIDINE AND TETRAHYDROTHIOPHENE DERIVATIVES AND THEIR USE AS A MEDICAMENT</title><author>MAO, HUA ; JHA, SUSHIL CHANDRA ; COMPERNOLLE, FRANS JOSEF CORNELIUS ; MEGENS, ANTONIUS ADRIANUS HENDRIKUS PETRUS ; KOZLECKI, TOMASZ ; HOORNAERT, GEORGES JOSEPH CORNELIUS ; TRABANCO-SUAREZ, ANDRES AVELINO ; KOUKNI, MOHAMED ; FERNANDEZ-GADEA, FRANCISCO JAVIER ; CID-NUNEZ, JOSE MARIA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2604165A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2006</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>MAO, HUA</creatorcontrib><creatorcontrib>JHA, SUSHIL CHANDRA</creatorcontrib><creatorcontrib>COMPERNOLLE, FRANS JOSEF CORNELIUS</creatorcontrib><creatorcontrib>MEGENS, ANTONIUS ADRIANUS HENDRIKUS PETRUS</creatorcontrib><creatorcontrib>KOZLECKI, TOMASZ</creatorcontrib><creatorcontrib>HOORNAERT, GEORGES JOSEPH CORNELIUS</creatorcontrib><creatorcontrib>TRABANCO-SUAREZ, ANDRES AVELINO</creatorcontrib><creatorcontrib>KOUKNI, MOHAMED</creatorcontrib><creatorcontrib>FERNANDEZ-GADEA, FRANCISCO JAVIER</creatorcontrib><creatorcontrib>CID-NUNEZ, JOSE MARIA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MAO, HUA</au><au>JHA, SUSHIL CHANDRA</au><au>COMPERNOLLE, FRANS JOSEF CORNELIUS</au><au>MEGENS, ANTONIUS ADRIANUS HENDRIKUS PETRUS</au><au>KOZLECKI, TOMASZ</au><au>HOORNAERT, GEORGES JOSEPH CORNELIUS</au><au>TRABANCO-SUAREZ, ANDRES AVELINO</au><au>KOUKNI, MOHAMED</au><au>FERNANDEZ-GADEA, FRANCISCO JAVIER</au><au>CID-NUNEZ, JOSE MARIA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>NOVEL SUBSTITUTED TETRACYCLIC TETRAHYDROFURAN, PYRROLIDINE AND TETRAHYDROTHIOPHENE DERIVATIVES AND THEIR USE AS A MEDICAMENT</title><date>2006-11-30</date><risdate>2006</risdate><abstract>This invention concerns novel substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives with binding affinities towards serotonin receptors, in particular 5-HT2A and 5-HT2C receptors, and towards dopamine receptors, in particular dopamine D2 receptors and with norepinephrine reuptake inhibition properties, pharmaceutical compositions comprising the compounds according to the invention, the use thereof as a medicine, in particular for the prevention and/or treatment of a range of psychiatric and neurological disorders, in particular certain psychotic, cardiovascular and gastrokinetic disorders and processes for their productio n. The compounds according to the invention can be represented by general Formu la (I), and comprises also the pharmaceutically acceptable acid or base additio n salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in Cla im 1.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | NOVEL SUBSTITUTED TETRACYCLIC TETRAHYDROFURAN, PYRROLIDINE AND TETRAHYDROTHIOPHENE DERIVATIVES AND THEIR USE AS A MEDICAMENT |
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