METHODS AND MEANS FOR DIAGNOSTICS, PREVENTION AND TREATMENT OF MYCOBACTERIUM INFECTIONS AND TUBERCULOSIS DISEASE

METHODS AND MEANS FOR DIAGNOSTICS, PREVENTION AND TREATMENT OF MYCOBACTERIUM INFECTIONS AND TUBERCULOSIS DISEASE

The invention identifies a narrow subset of Mycobacterium latency associated antigens and or epitopes that are capable of eliciting an immune response in vivo and in vitro in a mammal. The invention provides methods and compositions for detection and immunization against latent Mycobacterium infecti...

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Hauptverfasser: KLEIN, MICHEL ROBERT, OTTENHOF, TOM HENRICUS MARIA, FRANKEN, CORNELUS LEONARDUS MARIA COLETA, VAN MEIJGAARDEN, KRISTA ELISABETH, LIN, MIN YONG, LEYTEN, ELIANE MADELEINE SOPHIE
Format: Patent
Sprache:eng ; fre
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator KLEIN, MICHEL ROBERT
OTTENHOF, TOM HENRICUS MARIA
FRANKEN, CORNELUS LEONARDUS MARIA COLETA
VAN MEIJGAARDEN, KRISTA ELISABETH
LIN, MIN YONG
LEYTEN, ELIANE MADELEINE SOPHIE
description The invention identifies a narrow subset of Mycobacterium latency associated antigens and or epitopes that are capable of eliciting an immune response in vivo and in vitro in a mammal. The invention provides methods and compositions for detection and immunization against latent Mycobacterium infections. These compositions comprise those Mycobacterial latency antigens that are actually capable of eliciting an immune response in vivo, in mammals experiencing a latent Mycobacterium infection. More preferably the compositions comprise those antigens that are preferentially recognized by latently infected individuals and which antigens are not, or to a much lesser extent, recognized in individuals having an active Mycobacterium infection or in individuals having Mycobacterium induced symptoms or diseases, such as in patients infected with M. tuberculosis suffering from tuberculosis disease (TB).
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title METHODS AND MEANS FOR DIAGNOSTICS, PREVENTION AND TREATMENT OF MYCOBACTERIUM INFECTIONS AND TUBERCULOSIS DISEASE
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