METHOD OF PREPARING POLY(ADP-RIBOSE) POLYMERASES INHIBITORS

METHOD OF PREPARING POLY(ADP-RIBOSE) POLYMERASES INHIBITORS

This invention relates to a new and convergent route to small molecule inhibitors of poly(ADP-ribose) polymerase, such as 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one, via a key Sonogashira coupling reaction and a CuI-promoted indole formation.

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: MA, CHUNRONG, NAYYAR, NARESH, STANKOVIC, NEBOJSA SLOBODAN
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator MA, CHUNRONG
NAYYAR, NARESH
STANKOVIC, NEBOJSA SLOBODAN
description This invention relates to a new and convergent route to small molecule inhibitors of poly(ADP-ribose) polymerase, such as 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one, via a key Sonogashira coupling reaction and a CuI-promoted indole formation.
format Patent
fullrecord <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CA2580833A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CA2580833A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CA2580833A13</originalsourceid><addsrcrecordid>eNrjZLD2dQ3x8HdR8HdTCAhyDXAM8vRzVwjw94nUcHQJ0A3ydPIPdtUEC_i6BjkGuwYrePp5eDp5hvgHBfMwsKYl5hSn8kJpbgYFN9cQZw_d1IL8-NTigsTk1LzUknhnRyNTCwMLY2NHQ2MilAAAk_wo6g</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>METHOD OF PREPARING POLY(ADP-RIBOSE) POLYMERASES INHIBITORS</title><source>esp@cenet</source><creator>MA, CHUNRONG ; NAYYAR, NARESH ; STANKOVIC, NEBOJSA SLOBODAN</creator><creatorcontrib>MA, CHUNRONG ; NAYYAR, NARESH ; STANKOVIC, NEBOJSA SLOBODAN</creatorcontrib><description>This invention relates to a new and convergent route to small molecule inhibitors of poly(ADP-ribose) polymerase, such as 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one, via a key Sonogashira coupling reaction and a CuI-promoted indole formation.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2006</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20060330&amp;DB=EPODOC&amp;CC=CA&amp;NR=2580833A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76294</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20060330&amp;DB=EPODOC&amp;CC=CA&amp;NR=2580833A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MA, CHUNRONG</creatorcontrib><creatorcontrib>NAYYAR, NARESH</creatorcontrib><creatorcontrib>STANKOVIC, NEBOJSA SLOBODAN</creatorcontrib><title>METHOD OF PREPARING POLY(ADP-RIBOSE) POLYMERASES INHIBITORS</title><description>This invention relates to a new and convergent route to small molecule inhibitors of poly(ADP-ribose) polymerase, such as 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one, via a key Sonogashira coupling reaction and a CuI-promoted indole formation.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2006</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLD2dQ3x8HdR8HdTCAhyDXAM8vRzVwjw94nUcHQJ0A3ydPIPdtUEC_i6BjkGuwYrePp5eDp5hvgHBfMwsKYl5hSn8kJpbgYFN9cQZw_d1IL8-NTigsTk1LzUknhnRyNTCwMLY2NHQ2MilAAAk_wo6g</recordid><startdate>20060330</startdate><enddate>20060330</enddate><creator>MA, CHUNRONG</creator><creator>NAYYAR, NARESH</creator><creator>STANKOVIC, NEBOJSA SLOBODAN</creator><scope>EVB</scope></search><sort><creationdate>20060330</creationdate><title>METHOD OF PREPARING POLY(ADP-RIBOSE) POLYMERASES INHIBITORS</title><author>MA, CHUNRONG ; NAYYAR, NARESH ; STANKOVIC, NEBOJSA SLOBODAN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2580833A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2006</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>MA, CHUNRONG</creatorcontrib><creatorcontrib>NAYYAR, NARESH</creatorcontrib><creatorcontrib>STANKOVIC, NEBOJSA SLOBODAN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MA, CHUNRONG</au><au>NAYYAR, NARESH</au><au>STANKOVIC, NEBOJSA SLOBODAN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>METHOD OF PREPARING POLY(ADP-RIBOSE) POLYMERASES INHIBITORS</title><date>2006-03-30</date><risdate>2006</risdate><abstract>This invention relates to a new and convergent route to small molecule inhibitors of poly(ADP-ribose) polymerase, such as 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one, via a key Sonogashira coupling reaction and a CuI-promoted indole formation.</abstract><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier
ispartof
issn
language eng ; fre
recordid cdi_epo_espacenet_CA2580833A1
source esp@cenet
subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title METHOD OF PREPARING POLY(ADP-RIBOSE) POLYMERASES INHIBITORS
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T11%3A02%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=MA,%20CHUNRONG&rft.date=2006-03-30&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECA2580833A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true