KINASE MODULATORS AND METHODS OF USE

The present invention relates to compounds of the Formula (I) and (II) wherein R, R21, R25-R33, m, n, X21-X23, and Q1 are defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	LE, DONNA TRA, BUSSENIUS, JOERG, ANAND, NEEL K, CANNE BANNEN, LYNNE, JAMMALAMADAKA, VASU, DUBENKO, LARISA, COSTANZO, SIMONA, NUSS, JOHN M, HUANG, PING, CHAN, DIVA SZE-MING, KIM, MOON HWAN, KHOURY, RICHARD GEORGE, TSANG, TSZE H, CHEN, BAILI, KLEIN, RHETT RONALD, DEFINA, STEVEN CHARLES, FRANZINI, MAURIZIO, TSUHAKO, AMY LEW, WANG, YONG, PARKS, JASON JEVIOUS, BLAZEY, CHARLES M, XU, WEI, MAC, MORRISON B, BOWLES, OWEN JOSEPH, CO, ERICK WANG, RICE, KENNETH D
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention relates to compounds of the Formula (I) and (II) wherein R, R21, R25-R33, m, n, X21-X23, and Q1 are defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly p70S6 and/or Akt kinases. Methods of using and preparing the compounds, and pharmaceutical compositions thereof, to treat kinase-dependent diseases and conditions are also an aspect of the invention.