DIAZA-SPIROPIPERIDINE DERIVATIVES

The present invention relates to compounds of formula (I); wherein A-B is -CH2-CH2-, -CH2-O- or -O-CH2-; X is hydrogen or hydroxy; Rl is aryl, optionally substituted by one or two substituents, selected from the group consisting of halogen, lower alkyl, cyano, CF3, -OCF3, lower alkoxy, -SO2-lower al...

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Hauptverfasser:	PINARD, EMMANUEL, CECCARELLI, SIMONA MARIA, THOMAS, ANDREW WILLIAM, JOLIDON, SYNESE
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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creator	PINARD, EMMANUEL CECCARELLI, SIMONA MARIA THOMAS, ANDREW WILLIAM JOLIDON, SYNESE
description	The present invention relates to compounds of formula (I); wherein A-B is -CH2-CH2-, -CH2-O- or -O-CH2-; X is hydrogen or hydroxy; Rl is aryl, optionally substituted by one or two substituents, selected from the group consisting of halogen, lower alkyl, cyano, CF3, -OCF3, lower alkoxy, -SO2-lower alkyl or by heteroaryl, R2 is aryl, optionally substituted by one or two substituents, selected from the group consisting of halogen, lower alkyl, CF3 or lower alkoxy; R3 is hydrogen or lower alkyl; n is 0, 1 or 2; and to their pharmaceutically active salts. The compounds of formula I may be used in the treatment of neurological and neuropsychiatric disorders.
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The compounds of formula I may be used in the treatment of neurological and neuropsychiatric disorders.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2010</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20100914&DB=EPODOC&CC=CA&NR=2552914C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20100914&DB=EPODOC&CC=CA&NR=2552914C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>PINARD, EMMANUEL</creatorcontrib><creatorcontrib>CECCARELLI, SIMONA MARIA</creatorcontrib><creatorcontrib>THOMAS, ANDREW WILLIAM</creatorcontrib><creatorcontrib>JOLIDON, SYNESE</creatorcontrib><title>DIAZA-SPIROPIPERIDINE DERIVATIVES</title><description>The present invention relates to compounds of formula (I); wherein A-B is -CH2-CH2-, -CH2-O- or -O-CH2-; X is hydrogen or hydroxy; Rl is aryl, optionally substituted by one or two substituents, selected from the group consisting of halogen, lower alkyl, cyano, CF3, -OCF3, lower alkoxy, -SO2-lower alkyl or by heteroaryl, R2 is aryl, optionally substituted by one or two substituents, selected from the group consisting of halogen, lower alkyl, CF3 or lower alkoxy; R3 is hydrogen or lower alkyl; n is 0, 1 or 2; and to their pharmaceutically active salts. 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subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
title	DIAZA-SPIROPIPERIDINE DERIVATIVES
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