PREPARATION OF SUBSTITUTED QUINAZOLINES
Methods and materials for preparing irreversible inhibitors of tyrosine kinases of general Formula 1 are disclosed. Such inhibitors, which include N-[4-(3-chloro-4-floro-phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylamide, are useful for treating cancer, restenosis, atherosclerosis...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; fre |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | HEEMSTRA, RONALD JOSEPH BARTH, HUBERT GANGOLF KLEMENS STEINER, KLAUS IRENAUS MCNAMARA, DENNIS JOSEPH WINTERS, ROY THOMAS JACKS, THOMAS ELLIOTT TOOGOOD, PETER LAURENCE HORNE, NICOLE MARCIA HUGHES, ROBERT CRAIG BRIDGES, ALEXANDER JAMES SCHNEIDER, SIMON |
| description | Methods and materials for preparing irreversible inhibitors of tyrosine kinases of general Formula 1 are disclosed. Such inhibitors, which include N-[4-(3-chloro-4-floro-phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylamide, are useful for treating cancer, restenosis, atherosclerosis, endometriosis and psoriasis. The disclosed methods employ protecting schemes to minimize undesirable diacryloylamino-quinazoline side products. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CA2514933A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CA2514933A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CA2514933A13</originalsourceid><addsrcrecordid>eNrjZFAPCHINcAxyDPH091Pwd1MIDnUKDvEMCQ1xdVEIDPX0c4zy9_H0cw3mYWBNS8wpTuWF0twMCm6uIc4euqkF-fGpxQWJyal5qSXxzo5GpoYmlsbGjobGRCgBAM9MI8Y</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>PREPARATION OF SUBSTITUTED QUINAZOLINES</title><source>esp@cenet</source><creator>HEEMSTRA, RONALD JOSEPH ; BARTH, HUBERT GANGOLF KLEMENS ; STEINER, KLAUS IRENAUS ; MCNAMARA, DENNIS JOSEPH ; WINTERS, ROY THOMAS ; JACKS, THOMAS ELLIOTT ; TOOGOOD, PETER LAURENCE ; HORNE, NICOLE MARCIA ; HUGHES, ROBERT CRAIG ; BRIDGES, ALEXANDER JAMES ; SCHNEIDER, SIMON</creator><creatorcontrib>HEEMSTRA, RONALD JOSEPH ; BARTH, HUBERT GANGOLF KLEMENS ; STEINER, KLAUS IRENAUS ; MCNAMARA, DENNIS JOSEPH ; WINTERS, ROY THOMAS ; JACKS, THOMAS ELLIOTT ; TOOGOOD, PETER LAURENCE ; HORNE, NICOLE MARCIA ; HUGHES, ROBERT CRAIG ; BRIDGES, ALEXANDER JAMES ; SCHNEIDER, SIMON</creatorcontrib><description>Methods and materials for preparing irreversible inhibitors of tyrosine kinases of general Formula 1 are disclosed. Such inhibitors, which include N-[4-(3-chloro-4-floro-phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylamide, are useful for treating cancer, restenosis, atherosclerosis, endometriosis and psoriasis. The disclosed methods employ protecting schemes to minimize undesirable diacryloylamino-quinazoline side products.</description><edition>7</edition><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2004</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040819&DB=EPODOC&CC=CA&NR=2514933A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76516</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040819&DB=EPODOC&CC=CA&NR=2514933A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HEEMSTRA, RONALD JOSEPH</creatorcontrib><creatorcontrib>BARTH, HUBERT GANGOLF KLEMENS</creatorcontrib><creatorcontrib>STEINER, KLAUS IRENAUS</creatorcontrib><creatorcontrib>MCNAMARA, DENNIS JOSEPH</creatorcontrib><creatorcontrib>WINTERS, ROY THOMAS</creatorcontrib><creatorcontrib>JACKS, THOMAS ELLIOTT</creatorcontrib><creatorcontrib>TOOGOOD, PETER LAURENCE</creatorcontrib><creatorcontrib>HORNE, NICOLE MARCIA</creatorcontrib><creatorcontrib>HUGHES, ROBERT CRAIG</creatorcontrib><creatorcontrib>BRIDGES, ALEXANDER JAMES</creatorcontrib><creatorcontrib>SCHNEIDER, SIMON</creatorcontrib><title>PREPARATION OF SUBSTITUTED QUINAZOLINES</title><description>Methods and materials for preparing irreversible inhibitors of tyrosine kinases of general Formula 1 are disclosed. Such inhibitors, which include N-[4-(3-chloro-4-floro-phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylamide, are useful for treating cancer, restenosis, atherosclerosis, endometriosis and psoriasis. The disclosed methods employ protecting schemes to minimize undesirable diacryloylamino-quinazoline side products.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2004</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFAPCHINcAxyDPH091Pwd1MIDnUKDvEMCQ1xdVEIDPX0c4zy9_H0cw3mYWBNS8wpTuWF0twMCm6uIc4euqkF-fGpxQWJyal5qSXxzo5GpoYmlsbGjobGRCgBAM9MI8Y</recordid><startdate>20040819</startdate><enddate>20040819</enddate><creator>HEEMSTRA, RONALD JOSEPH</creator><creator>BARTH, HUBERT GANGOLF KLEMENS</creator><creator>STEINER, KLAUS IRENAUS</creator><creator>MCNAMARA, DENNIS JOSEPH</creator><creator>WINTERS, ROY THOMAS</creator><creator>JACKS, THOMAS ELLIOTT</creator><creator>TOOGOOD, PETER LAURENCE</creator><creator>HORNE, NICOLE MARCIA</creator><creator>HUGHES, ROBERT CRAIG</creator><creator>BRIDGES, ALEXANDER JAMES</creator><creator>SCHNEIDER, SIMON</creator><scope>EVB</scope></search><sort><creationdate>20040819</creationdate><title>PREPARATION OF SUBSTITUTED QUINAZOLINES</title><author>HEEMSTRA, RONALD JOSEPH ; BARTH, HUBERT GANGOLF KLEMENS ; STEINER, KLAUS IRENAUS ; MCNAMARA, DENNIS JOSEPH ; WINTERS, ROY THOMAS ; JACKS, THOMAS ELLIOTT ; TOOGOOD, PETER LAURENCE ; HORNE, NICOLE MARCIA ; HUGHES, ROBERT CRAIG ; BRIDGES, ALEXANDER JAMES ; SCHNEIDER, SIMON</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2514933A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2004</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>HEEMSTRA, RONALD JOSEPH</creatorcontrib><creatorcontrib>BARTH, HUBERT GANGOLF KLEMENS</creatorcontrib><creatorcontrib>STEINER, KLAUS IRENAUS</creatorcontrib><creatorcontrib>MCNAMARA, DENNIS JOSEPH</creatorcontrib><creatorcontrib>WINTERS, ROY THOMAS</creatorcontrib><creatorcontrib>JACKS, THOMAS ELLIOTT</creatorcontrib><creatorcontrib>TOOGOOD, PETER LAURENCE</creatorcontrib><creatorcontrib>HORNE, NICOLE MARCIA</creatorcontrib><creatorcontrib>HUGHES, ROBERT CRAIG</creatorcontrib><creatorcontrib>BRIDGES, ALEXANDER JAMES</creatorcontrib><creatorcontrib>SCHNEIDER, SIMON</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HEEMSTRA, RONALD JOSEPH</au><au>BARTH, HUBERT GANGOLF KLEMENS</au><au>STEINER, KLAUS IRENAUS</au><au>MCNAMARA, DENNIS JOSEPH</au><au>WINTERS, ROY THOMAS</au><au>JACKS, THOMAS ELLIOTT</au><au>TOOGOOD, PETER LAURENCE</au><au>HORNE, NICOLE MARCIA</au><au>HUGHES, ROBERT CRAIG</au><au>BRIDGES, ALEXANDER JAMES</au><au>SCHNEIDER, SIMON</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PREPARATION OF SUBSTITUTED QUINAZOLINES</title><date>2004-08-19</date><risdate>2004</risdate><abstract>Methods and materials for preparing irreversible inhibitors of tyrosine kinases of general Formula 1 are disclosed. Such inhibitors, which include N-[4-(3-chloro-4-floro-phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylamide, are useful for treating cancer, restenosis, atherosclerosis, endometriosis and psoriasis. The disclosed methods employ protecting schemes to minimize undesirable diacryloylamino-quinazoline side products.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; fre |
| recordid | cdi_epo_espacenet_CA2514933A1 |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | PREPARATION OF SUBSTITUTED QUINAZOLINES |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-15T18%3A27%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=HEEMSTRA,%20RONALD%20JOSEPH&rft.date=2004-08-19&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECA2514933A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |