INHIBITORS OF HUMAN TUMOR-EXPRESSED CCXCKR2

Pharmaceutical compositions containing organic compounds of formula (I) or salts thereof that serve as modulators for the SDF-1 or I-TAC chemokines are disclosed. The compounds and compositions are useful in the treatment of cancer, especially in the inhibition of cancer proliferation, growth, and m...

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Bibliographische Detailangaben
Hauptverfasser:	MELIKIAN, ANITA, WRIGHT, JOHN J, SCHALL, THOMAS, BURNS, JENNIFER, MCMASTER, BRIAN E
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Pharmaceutical compositions containing organic compounds of formula (I) or salts thereof that serve as modulators for the SDF-1 or I-TAC chemokines are disclosed. The compounds and compositions are useful in the treatment of cancer, especially in the inhibition of cancer proliferation, growth, and metastasis. Methods of interfering with SDF-1 and/or I-TAC binding to the CCXCKR2 receptor and treating cancer using the compounds and pharmaceutical compositions of the present invention are also disclosed. L'invention concerne des compositions pharmaceutiques contenant des composés organiques ou leurs sels, qui servent de modulateurs des chimiokines SDF-1 ou I-TAC. Ces composés et compositions sont utiles dans le traitement du cancer, notamment dans l'inhibition de la prolifération et de la croissance cancéreuse et de la métastéase. L'invention concerne également des procédés d'interférence avec la liaison de SDF-1 et/ou I-TAC au récepteur CCXCKR2 et le traitement du cancer à l'aide des composés et compositions pharmaceutiques de la présente invention.