QUINAZOLINONES AS POTASSIUM CHANNEL MODULATORS

QUINAZOLINONES AS POTASSIUM CHANNEL MODULATORS

Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides quinazolinone, compositions and methods that are useful in the treatment...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: MCNAUGHTON-SMITH, GRANT ANDREW, AMATO, GEORGE SALVATORE, THOMAS, JAMES BARNWELL, JR
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator MCNAUGHTON-SMITH, GRANT ANDREW
AMATO, GEORGE SALVATORE
THOMAS, JAMES BARNWELL, JR
description Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides quinazolinone, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders (e.g., migraine, ataxia, Parkinson's disease, bipolar disorders, trigeminal neuralgia, spasticity, mood disorders, brain tumors, psychotic disorders, myokymia, seizures, epilepsy, hearing and vision loss, Alzheimer's disease, age-relate d memory loss, learning deficiencies, anxiety and motor neuron diseases) and a s neuroprotective agents (e.g., to prevent stroke and the like) by modulating potassium channels associated with the onset or recurrence of the indicated conditions.
format Patent
fullrecord <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CA2505195A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CA2505195A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CA2505195A13</originalsourceid><addsrcrecordid>eNrjZNALDPX0c4zy9_H08_dzDVZwDFYI8A9xDA72DPVVcPZw9PNz9VHw9XcJ9XEM8Q8K5mFgTUvMKU7lhdLcDApuriHOHrqpBfnxqcUFicmpeakl8c6ORqYGpoaWpo6GxkQoAQDLViWs</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>QUINAZOLINONES AS POTASSIUM CHANNEL MODULATORS</title><source>esp@cenet</source><creator>MCNAUGHTON-SMITH, GRANT ANDREW ; AMATO, GEORGE SALVATORE ; THOMAS, JAMES BARNWELL, JR</creator><creatorcontrib>MCNAUGHTON-SMITH, GRANT ANDREW ; AMATO, GEORGE SALVATORE ; THOMAS, JAMES BARNWELL, JR</creatorcontrib><description>Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides quinazolinone, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders (e.g., migraine, ataxia, Parkinson's disease, bipolar disorders, trigeminal neuralgia, spasticity, mood disorders, brain tumors, psychotic disorders, myokymia, seizures, epilepsy, hearing and vision loss, Alzheimer's disease, age-relate d memory loss, learning deficiencies, anxiety and motor neuron diseases) and a s neuroprotective agents (e.g., to prevent stroke and the like) by modulating potassium channels associated with the onset or recurrence of the indicated conditions.</description><edition>7</edition><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2004</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20040715&amp;DB=EPODOC&amp;CC=CA&amp;NR=2505195A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20040715&amp;DB=EPODOC&amp;CC=CA&amp;NR=2505195A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MCNAUGHTON-SMITH, GRANT ANDREW</creatorcontrib><creatorcontrib>AMATO, GEORGE SALVATORE</creatorcontrib><creatorcontrib>THOMAS, JAMES BARNWELL, JR</creatorcontrib><title>QUINAZOLINONES AS POTASSIUM CHANNEL MODULATORS</title><description>Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides quinazolinone, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders (e.g., migraine, ataxia, Parkinson's disease, bipolar disorders, trigeminal neuralgia, spasticity, mood disorders, brain tumors, psychotic disorders, myokymia, seizures, epilepsy, hearing and vision loss, Alzheimer's disease, age-relate d memory loss, learning deficiencies, anxiety and motor neuron diseases) and a s neuroprotective agents (e.g., to prevent stroke and the like) by modulating potassium channels associated with the onset or recurrence of the indicated conditions.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2004</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNALDPX0c4zy9_H08_dzDVZwDFYI8A9xDA72DPVVcPZw9PNz9VHw9XcJ9XEM8Q8K5mFgTUvMKU7lhdLcDApuriHOHrqpBfnxqcUFicmpeakl8c6ORqYGpoaWpo6GxkQoAQDLViWs</recordid><startdate>20040715</startdate><enddate>20040715</enddate><creator>MCNAUGHTON-SMITH, GRANT ANDREW</creator><creator>AMATO, GEORGE SALVATORE</creator><creator>THOMAS, JAMES BARNWELL, JR</creator><scope>EVB</scope></search><sort><creationdate>20040715</creationdate><title>QUINAZOLINONES AS POTASSIUM CHANNEL MODULATORS</title><author>MCNAUGHTON-SMITH, GRANT ANDREW ; AMATO, GEORGE SALVATORE ; THOMAS, JAMES BARNWELL, JR</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2505195A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2004</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>MCNAUGHTON-SMITH, GRANT ANDREW</creatorcontrib><creatorcontrib>AMATO, GEORGE SALVATORE</creatorcontrib><creatorcontrib>THOMAS, JAMES BARNWELL, JR</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MCNAUGHTON-SMITH, GRANT ANDREW</au><au>AMATO, GEORGE SALVATORE</au><au>THOMAS, JAMES BARNWELL, JR</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>QUINAZOLINONES AS POTASSIUM CHANNEL MODULATORS</title><date>2004-07-15</date><risdate>2004</risdate><abstract>Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides quinazolinone, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders (e.g., migraine, ataxia, Parkinson's disease, bipolar disorders, trigeminal neuralgia, spasticity, mood disorders, brain tumors, psychotic disorders, myokymia, seizures, epilepsy, hearing and vision loss, Alzheimer's disease, age-relate d memory loss, learning deficiencies, anxiety and motor neuron diseases) and a s neuroprotective agents (e.g., to prevent stroke and the like) by modulating potassium channels associated with the onset or recurrence of the indicated conditions.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier
ispartof
issn
language eng ; fre
recordid cdi_epo_espacenet_CA2505195A1
source esp@cenet
subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title QUINAZOLINONES AS POTASSIUM CHANNEL MODULATORS
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T04%3A20%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=MCNAUGHTON-SMITH,%20GRANT%20ANDREW&rft.date=2004-07-15&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECA2505195A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true