BOTULINUM NEUROTOXIN B RECEPTORS AND USE THEREOF
It is disclosed here that synaptotagmin I (syt I) and synaptotagmin II (syt II) are the cellular receptors for botulinum neurotoxin B (BoNT/B) that mediate the cellular entry and toxicity of BoNT/B. The BoNT/B binding domain s of syt I and II are also disclosed. While syt I needs gangliosides for Bo...
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| creator | CHAPMAN, EDWIN RAYMOND DONG, MIN |
| description | It is disclosed here that synaptotagmin I (syt I) and synaptotagmin II (syt II) are the cellular receptors for botulinum neurotoxin B (BoNT/B) that mediate the cellular entry and toxicity of BoNT/B. The BoNT/B binding domain s of syt I and II are also disclosed. While syt I needs gangliosides for BoNT/ B binding, syt II can bind to BoNT/B in the absence of gangliosides. Various nucleic acids and polypeptides that relate to the BoNT/B binding domain of s yt I or II are disclosed. Further disclosed are methods of reducing BoNT/B toxicity, methods of identifying agents that can block the binding between BoNT/B and syt I or II, methods of identifying agents that can bind to the BoNT/B binding domain of syt I or II, and methods of detecting BoNT/B or Clostridium botulinum. |
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The BoNT/B binding domain s of syt I and II are also disclosed. While syt I needs gangliosides for BoNT/ B binding, syt II can bind to BoNT/B in the absence of gangliosides. Various nucleic acids and polypeptides that relate to the BoNT/B binding domain of s yt I or II are disclosed. Further disclosed are methods of reducing BoNT/B toxicity, methods of identifying agents that can block the binding between BoNT/B and syt I or II, methods of identifying agents that can bind to the BoNT/B binding domain of syt I or II, and methods of detecting BoNT/B or Clostridium botulinum.</description><edition>7</edition><language>eng ; fre</language><subject>CHEMISTRY ; DERIVATIVES THEREOF ; METALLURGY ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; PEPTIDES ; SUGARS</subject><creationdate>2005</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20050224&DB=EPODOC&CC=CA&NR=2504532A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20050224&DB=EPODOC&CC=CA&NR=2504532A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CHAPMAN, EDWIN RAYMOND</creatorcontrib><creatorcontrib>DONG, MIN</creatorcontrib><title>BOTULINUM NEUROTOXIN B RECEPTORS AND USE THEREOF</title><description>It is disclosed here that synaptotagmin I (syt I) and synaptotagmin II (syt II) are the cellular receptors for botulinum neurotoxin B (BoNT/B) that mediate the cellular entry and toxicity of BoNT/B. 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Further disclosed are methods of reducing BoNT/B toxicity, methods of identifying agents that can block the binding between BoNT/B and syt I or II, methods of identifying agents that can bind to the BoNT/B binding domain of syt I or II, and methods of detecting BoNT/B or Clostridium botulinum.</description><subject>CHEMISTRY</subject><subject>DERIVATIVES THEREOF</subject><subject>METALLURGY</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>SUGARS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2005</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDBw8g8J9fH0C_VV8HMNDfIP8Y_w9FNwUghydXYNCPEPClZw9HNRCA12VQjxcA1y9XfjYWBNS8wpTuWF0twMCm6uIc4euqkF-fGpxQWJyal5qSXxzo5GpgYmpsZGjobGRCgBAPtMJec</recordid><startdate>20050224</startdate><enddate>20050224</enddate><creator>CHAPMAN, EDWIN RAYMOND</creator><creator>DONG, MIN</creator><scope>EVB</scope></search><sort><creationdate>20050224</creationdate><title>BOTULINUM NEUROTOXIN B RECEPTORS AND USE THEREOF</title><author>CHAPMAN, EDWIN RAYMOND ; DONG, MIN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2504532A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2005</creationdate><topic>CHEMISTRY</topic><topic>DERIVATIVES THEREOF</topic><topic>METALLURGY</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>SUGARS</topic><toplevel>online_resources</toplevel><creatorcontrib>CHAPMAN, EDWIN RAYMOND</creatorcontrib><creatorcontrib>DONG, MIN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CHAPMAN, EDWIN RAYMOND</au><au>DONG, MIN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>BOTULINUM NEUROTOXIN B RECEPTORS AND USE THEREOF</title><date>2005-02-24</date><risdate>2005</risdate><abstract>It is disclosed here that synaptotagmin I (syt I) and synaptotagmin II (syt II) are the cellular receptors for botulinum neurotoxin B (BoNT/B) that mediate the cellular entry and toxicity of BoNT/B. 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| subjects | CHEMISTRY DERIVATIVES THEREOF METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PEPTIDES SUGARS |
| title | BOTULINUM NEUROTOXIN B RECEPTORS AND USE THEREOF |
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