DIVALPROEX SODIUM DOSAGE FORMS AND A PROCESS FOR THEIR PRODUCTION

DIVALPROEX SODIUM DOSAGE FORMS AND A PROCESS FOR THEIR PRODUCTION

The present invention is directed to a new process for granulating valproate compounds, such as divalproex sodium, in which the compound is melted in the absence of a binder and admixed with one or more excipients to produce granules. The resulting dosage forms have an increased drug loading factor...

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Hauptverfasser: CHERMAK, TODD E, QIU, YIHONG, FAITSCH, LYNN, SLADE, RUSSELL T, ENGH, KEVIN R
Format: Patent
Sprache:eng ; fre
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator CHERMAK, TODD E
QIU, YIHONG
FAITSCH, LYNN
SLADE, RUSSELL T
ENGH, KEVIN R
description The present invention is directed to a new process for granulating valproate compounds, such as divalproex sodium, in which the compound is melted in the absence of a binder and admixed with one or more excipients to produce granules. The resulting dosage forms have an increased drug loading factor i n the range of 75 w/w% to 90 w/w%.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title DIVALPROEX SODIUM DOSAGE FORMS AND A PROCESS FOR THEIR PRODUCTION
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