A METHOD OF PRODUCING SUSTAINED-RELEASE PREPARATIONS OF A BIOACTIVE SUBSTANCE USING HIGH-PRESSURE GAS

A METHOD OF PRODUCING SUSTAINED-RELEASE PREPARATIONS OF A BIOACTIVE SUBSTANCE USING HIGH-PRESSURE GAS

A method for producing a preparation containing a bioactive substance, characterized in that it comprises forming a solid material containing the bioactive substance and a polymer, and contacting the solid material with a high pressure gas. The method allows the production of a preparation which is...

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Hauptverfasser: MISAKI, MASAFUMI, TAKADA, SHIGEYUKI, OHMACHI, YOSHIHIRO
Format: Patent
Sprache:eng ; fre
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator MISAKI, MASAFUMI
TAKADA, SHIGEYUKI
OHMACHI, YOSHIHIRO
description A method for producing a preparation containing a bioactive substance, characterized in that it comprises forming a solid material containing the bioactive substance and a polymer, and contacting the solid material with a high pressure gas. The method allows the production of a preparation which is suppressed in excessive initial release of the bioactive substance immediately after the administration thereof, is capable of releasing a predetermined amount of the bioactive substance over a long period of time, and is extremely reduced in the deterioration of the bioactive substance and in the amount of a residual organic solvent.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title A METHOD OF PRODUCING SUSTAINED-RELEASE PREPARATIONS OF A BIOACTIVE SUBSTANCE USING HIGH-PRESSURE GAS
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