BARBITURIC ACID ANALOGS AS THERAPEUTIC AGENTS

This invention pertains to active barbituric acid analogs which inhibit HIF- 1 activity (e.g., the interaction between HIF-1.alpha. and p300) and thereby inhibit angiogenesis, tumorigenesis, and proliferative conditions, such as cancer. The present invention also pertains to pharmaceutical compositi...

Ausführliche Beschreibung

Bibliographische Detailangaben

Hauptverfasser:	RYLEY, STEPHEN, ROMERO-MARTIN, MARIA-ROSARIO, LAW, NORMAN M, FINN, PAUL W, BILLINGTON, DAVID C, SAYERS, LEE G, DE BELIN, JACKIE Y, BHATTACHARYA, SHOUMO
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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