THROMBIN INHIBITORS

Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions and are selected from the group (I) or a pharmaceutically acceptable salt thereof, wherein T is selected from the gro up (II) and (III), and ;D, E, F, G, H, I, and J are independently N or C Y1, provide...

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Bibliographische Detailangaben
Hauptverfasser:	BARROW, JAMES C, NGO, PHUNG L, DORSEY, BRUCE D, SELNICK, HAROLD G
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES CHEMISTRY DISINFECTION, STERILISATION, OR DEODORISATION OF AIR HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METALLURGY METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions and are selected from the group (I) or a pharmaceutically acceptable salt thereof, wherein T is selected from the gro up (II) and (III), and ;D, E, F, G, H, I, and J are independently N or C Y1, provided that the number of such variables D, E, F, G, H, I, and J representing N is 0, 1, or 2; K, L, M and Q are independently NH or C Y1Y2, provided that the number of such variables D, E, F, K, L, M, and Q representing N is 0, 1, or 2;Y1 and Y2 are independently selected from the group consisting of hydrogen, C1-4 alkyl, halogen, amino, or hydroxy; A is (IV), (V), (VI), or (VII).