PROCESS FOR MAKING MORPHINE-6-GLUCURONIDE AND ITS ANALOGUES USING HALOGLUCURONATE ESTER INTERMEDIATES

A process is provided for the manufacture of morphine-6-glucuronide and related compounds of the general structure shown in Formula (1), wherein optionally substituted morphine is conjugated with an optionally substituted member of a new class of intermediates, namely 1-haloglucuronate esters, in th...

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Hauptverfasser:	LAW, JANE LOUISE, FERGUSON, JOHN, SCHEINMANN, FEODOR, STACHULSKI, ANDREW VALENTINE
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	APPARATUS THEREFOR CHEMISTRY DERIVATIVES THEREOF GENERAL METHODS OF ORGANIC CHEMISTRY METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY SUGARS
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creator	LAW, JANE LOUISE FERGUSON, JOHN SCHEINMANN, FEODOR STACHULSKI, ANDREW VALENTINE
description	A process is provided for the manufacture of morphine-6-glucuronide and related compounds of the general structure shown in Formula (1), wherein optionally substituted morphine is conjugated with an optionally substituted member of a new class of intermediates, namely 1-haloglucuronate esters, in the presence of iodine or an iodonium compound. This may be followed by a conversion of R1 (Formula (1)) into hydrogen and/or the removal of the ester groups from the glucuronic residue at R2 (Formula (1)).
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subjects	APPARATUS THEREFOR CHEMISTRY DERIVATIVES THEREOF GENERAL METHODS OF ORGANIC CHEMISTRY METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY SUGARS
title	PROCESS FOR MAKING MORPHINE-6-GLUCURONIDE AND ITS ANALOGUES USING HALOGLUCURONATE ESTER INTERMEDIATES
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