HIGH PURITY (1R,2S,4R)-(-)-2-[(2'-{N,N-DIMETHYLAMINO}-ETHOXY)]-2-[PHENYL]-1,7,7-TRI-[METHYL]-BICYCLO[2.2.1]HEPTANE AND PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF, PROCESS FOR THE PREPARATION OF THESE COMPOUNDS AS WELL AS MEDICAMENTS CONTAINING 1 OR MORE OF THESE COMPOUNDS AND THEIR USE

The invention relates to high purity (1R,2S,4R)-(-)-2- [(2'-{N,N-dimethylamino} -ethoxy)] -2-[phenyl] -1,7,7-tri-[methyl] -bicyclo[2.2.1] heptane and pharmaceutically acceptable acid addition salts thereof containing not more than 0.2 % of (1R,3S,4R)-3- [(2'-{N,N- dimethylamino} -ethyl)]-1...

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Hauptverfasser: PORCS-MAKKAY, MARTA, SIMIG, GYULA, NEMETH, NORBERT, VERECZKEYNE DONATH, GYORGYI, NAGY, KALMAN, BUDAI, ZOLTAN, LUKACS, GYULA, MEZEI, TIBOR, KRASZNAI, GYORGY, SZABO, TIBOR, SZULAGYI, JANOS
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creator PORCS-MAKKAY, MARTA
SIMIG, GYULA
NEMETH, NORBERT
VERECZKEYNE DONATH, GYORGYI
NAGY, KALMAN
BUDAI, ZOLTAN
LUKACS, GYULA
MEZEI, TIBOR
KRASZNAI, GYORGY
SZABO, TIBOR
SZULAGYI, JANOS
description The invention relates to high purity (1R,2S,4R)-(-)-2- [(2'-{N,N-dimethylamino} -ethoxy)] -2-[phenyl] -1,7,7-tri-[methyl] -bicyclo[2.2.1] heptane and pharmaceutically acceptable acid addition salts thereof containing not more than 0.2 % of (1R,3S,4R)-3- [(2'-{N,N- dimethylamino} -ethyl)]-1,7,7-tri- [methyl] -bicyclo [2.2.1] heptane-2-one and/or of a pharmaceutically acceptable acid addition salt thereof. Furthermore the invention is concerned with a process for the preparation of these compounds. Moreover the invention relates to medicaments containing 1 or more of these compounds and their use.
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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title HIGH PURITY (1R,2S,4R)-(-)-2-[(2'-{N,N-DIMETHYLAMINO}-ETHOXY)]-2-[PHENYL]-1,7,7-TRI-[METHYL]-BICYCLO[2.2.1]HEPTANE AND PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF, PROCESS FOR THE PREPARATION OF THESE COMPOUNDS AS WELL AS MEDICAMENTS CONTAINING 1 OR MORE OF THESE COMPOUNDS AND THEIR USE
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