TRICYCLIC .DELTA.3-PIPERIDINES AS .ALPHA.2-ANTAGONISTS
The present invention concerns the compounds of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Alk is C1-6alkanediyl; n is 1 or 2; X1 is -O-, -S-, -S(=O)- or -S(=O)2-; each R1 is independently hydrogen, halogen,...
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| creator | MERTENS, JOSEPHUS CAROLUS KENNIS, LUDO EDMOND JOSEPHINE VAN DEN KEYBUS, FRANS MARIA ALFONS |
| description | The present invention concerns the compounds of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Alk is C1-6alkanediyl; n is 1 or 2; X1 is -O-, -S-, -S(=O)- or -S(=O)2-; each R1 is independently hydrogen, halogen, C1-6alkyl, nitro, hydroxy or C1-4alkyloxy; D is an optionally substituted mono, bi- or tricyclic nitrogen containing heterocycle, a 2H-benzopyranone, a benzamide, a benzophenone or a phenoxyphenyl having central .alpha.2-adrenoceptor antagonist activity. It further relates to their preparation, pharmaceutical use and compositions. |
| format | Patent |
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It further relates to their preparation, pharmaceutical use and compositions.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2007</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20071204&DB=EPODOC&CC=CA&NR=2345622C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25562,76317</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20071204&DB=EPODOC&CC=CA&NR=2345622C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MERTENS, JOSEPHUS CAROLUS</creatorcontrib><creatorcontrib>KENNIS, LUDO EDMOND JOSEPHINE</creatorcontrib><creatorcontrib>VAN DEN KEYBUS, FRANS MARIA ALFONS</creatorcontrib><title>TRICYCLIC .DELTA.3-PIPERIDINES AS .ALPHA.2-ANTAGONISTS</title><description>The present invention concerns the compounds of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Alk is C1-6alkanediyl; n is 1 or 2; X1 is -O-, -S-, -S(=O)- or -S(=O)2-; each R1 is independently hydrogen, halogen, C1-6alkyl, nitro, hydroxy or C1-4alkyloxy; D is an optionally substituted mono, bi- or tricyclic nitrogen containing heterocycle, a 2H-benzopyranone, a benzamide, a benzophenone or a phenoxyphenyl having central .alpha.2-adrenoceptor antagonist activity. It further relates to their preparation, pharmaceutical use and compositions.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2007</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDALCfJ0jnT28XRW0HNx9Qlx1DPWDfAMcA3ydPH0cw1WcAxW0HP0CfBw1DPSdfQLcXT39_MMDgnmYWBNS8wpTuWF0twM8m6uIc4euqkF-fGpxQWJyal5qSXxzo5GxiamZkZGzsaEVQAAS3Ummw</recordid><startdate>20071204</startdate><enddate>20071204</enddate><creator>MERTENS, JOSEPHUS CAROLUS</creator><creator>KENNIS, LUDO EDMOND JOSEPHINE</creator><creator>VAN DEN KEYBUS, FRANS MARIA ALFONS</creator><scope>EVB</scope></search><sort><creationdate>20071204</creationdate><title>TRICYCLIC .DELTA.3-PIPERIDINES AS .ALPHA.2-ANTAGONISTS</title><author>MERTENS, JOSEPHUS CAROLUS ; KENNIS, LUDO EDMOND JOSEPHINE ; VAN DEN KEYBUS, FRANS MARIA ALFONS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2345622C3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2007</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>MERTENS, JOSEPHUS CAROLUS</creatorcontrib><creatorcontrib>KENNIS, LUDO EDMOND JOSEPHINE</creatorcontrib><creatorcontrib>VAN DEN KEYBUS, FRANS MARIA ALFONS</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MERTENS, JOSEPHUS CAROLUS</au><au>KENNIS, LUDO EDMOND JOSEPHINE</au><au>VAN DEN KEYBUS, FRANS MARIA ALFONS</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>TRICYCLIC .DELTA.3-PIPERIDINES AS .ALPHA.2-ANTAGONISTS</title><date>2007-12-04</date><risdate>2007</risdate><abstract>The present invention concerns the compounds of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Alk is C1-6alkanediyl; n is 1 or 2; X1 is -O-, -S-, -S(=O)- or -S(=O)2-; each R1 is independently hydrogen, halogen, C1-6alkyl, nitro, hydroxy or C1-4alkyloxy; D is an optionally substituted mono, bi- or tricyclic nitrogen containing heterocycle, a 2H-benzopyranone, a benzamide, a benzophenone or a phenoxyphenyl having central .alpha.2-adrenoceptor antagonist activity. It further relates to their preparation, pharmaceutical use and compositions.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | TRICYCLIC .DELTA.3-PIPERIDINES AS .ALPHA.2-ANTAGONISTS |
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