METABOTROPIC GABA RECEPTOR COMPLEX ISSUED FROM THE CENTRAL NERVOUS SYSTEM
The invention relates to isolated proteins which code for metabotropic GABA receptors and which, together with GABAB receptor proteins, form a metabotropic GABA receptor complex (= protein heteromer). The invention also relates to nucleic acid sequences or recombinant nucleic acid constructs whi ch...
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| creator | EISENHARDT, GISELA HIRSCHFELD, KIRSTEN KORNAU, HANSRISTIAN KUNER, ROHINI |
| description | The invention relates to isolated proteins which code for metabotropic GABA receptors and which, together with GABAB receptor proteins, form a metabotropic GABA receptor complex (= protein heteromer). The invention also relates to nucleic acid sequences or recombinant nucleic acid constructs whi ch code for the proteins. In addition, the invention relates to host organisms or transgenic animals containing the nucleic acid sequences or the recombinant nucleic acid constructs and to monoclonal or polyclonal antibodies which are directed against the isolated proteins. The invention also relates to a meth od for locating substances with a specific affinity to binding to the inventive novel GABA receptors or to the inventive GABA receptor complexes, to a metho d for qualitatively or quantitatively detecting the inventive nucleic acid sequences or the inventive proteins, and to a method for locating substances which specifically bind to an inventive GABA receptor or to an inventive nucleic acid sequence. The invention also relates to the use of the nucleic acid sequences and proteins. Finally, the invention relates to substances wi th which the activity of metabotropic GABA receptors can be influenced by influencing the stability of the protein heteromer. |
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The invention also relates to nucleic acid sequences or recombinant nucleic acid constructs whi ch code for the proteins. In addition, the invention relates to host organisms or transgenic animals containing the nucleic acid sequences or the recombinant nucleic acid constructs and to monoclonal or polyclonal antibodies which are directed against the isolated proteins. The invention also relates to a meth od for locating substances with a specific affinity to binding to the inventive novel GABA receptors or to the inventive GABA receptor complexes, to a metho d for qualitatively or quantitatively detecting the inventive nucleic acid sequences or the inventive proteins, and to a method for locating substances which specifically bind to an inventive GABA receptor or to an inventive nucleic acid sequence. The invention also relates to the use of the nucleic acid sequences and proteins. Finally, the invention relates to substances wi th which the activity of metabotropic GABA receptors can be influenced by influencing the stability of the protein heteromer.</description><edition>7</edition><language>eng ; fre</language><subject>AGRICULTURE ; ANIMAL HUSBANDRY ; BEER ; BIOCHEMISTRY ; CARE OF BIRDS, FISHES, INSECTS ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; COMPOSITIONS THEREOF ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; CULTURE MEDIA ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; FISHING ; FORESTRY ; HUMAN NECESSITIES ; HUNTING ; HYGIENE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; NEW BREEDS OF ANIMALS ; ORGANIC CHEMISTRY ; PEPTIDES ; PHYSICS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; TESTING ; TRAPPING ; VINEGAR ; WINE</subject><creationdate>2000</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20000323&DB=EPODOC&CC=CA&NR=2343574A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20000323&DB=EPODOC&CC=CA&NR=2343574A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>EISENHARDT, GISELA</creatorcontrib><creatorcontrib>HIRSCHFELD, KIRSTEN</creatorcontrib><creatorcontrib>KORNAU, HANSRISTIAN</creatorcontrib><creatorcontrib>KUNER, ROHINI</creatorcontrib><title>METABOTROPIC GABA RECEPTOR COMPLEX ISSUED FROM THE CENTRAL NERVOUS SYSTEM</title><description>The invention relates to isolated proteins which code for metabotropic GABA receptors and which, together with GABAB receptor proteins, form a metabotropic GABA receptor complex (= protein heteromer). The invention also relates to nucleic acid sequences or recombinant nucleic acid constructs whi ch code for the proteins. In addition, the invention relates to host organisms or transgenic animals containing the nucleic acid sequences or the recombinant nucleic acid constructs and to monoclonal or polyclonal antibodies which are directed against the isolated proteins. The invention also relates to a meth od for locating substances with a specific affinity to binding to the inventive novel GABA receptors or to the inventive GABA receptor complexes, to a metho d for qualitatively or quantitatively detecting the inventive nucleic acid sequences or the inventive proteins, and to a method for locating substances which specifically bind to an inventive GABA receptor or to an inventive nucleic acid sequence. The invention also relates to the use of the nucleic acid sequences and proteins. Finally, the invention relates to substances wi th which the activity of metabotropic GABA receptors can be influenced by influencing the stability of the protein heteromer.</description><subject>AGRICULTURE</subject><subject>ANIMAL HUSBANDRY</subject><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CARE OF BIRDS, FISHES, INSECTS</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>COMPOSITIONS THEREOF</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>FISHING</subject><subject>FORESTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HUNTING</subject><subject>HYGIENE</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>NEW BREEDS OF ANIMALS</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PHYSICS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>TRAPPING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2000</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyrEKwkAMANAuDqL-Q37AQa_inMbUHvSaI5eKTqXIOYkW6v_j4gc4veUtCx_YsBJTiZ7gjBWCMnE0USAJseUr-JR6PkGtEsAaBuLOFFvoWC_SJ0i3ZBzWxeIxPue8-bkqoGajZpun95DnabznV_4MhHtXusOxxJ37o3wB9LIs4A</recordid><startdate>20000323</startdate><enddate>20000323</enddate><creator>EISENHARDT, GISELA</creator><creator>HIRSCHFELD, KIRSTEN</creator><creator>KORNAU, HANSRISTIAN</creator><creator>KUNER, ROHINI</creator><scope>EVB</scope></search><sort><creationdate>20000323</creationdate><title>METABOTROPIC GABA RECEPTOR COMPLEX ISSUED FROM THE CENTRAL NERVOUS SYSTEM</title><author>EISENHARDT, GISELA ; HIRSCHFELD, KIRSTEN ; KORNAU, HANSRISTIAN ; KUNER, ROHINI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2343574A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2000</creationdate><topic>AGRICULTURE</topic><topic>ANIMAL HUSBANDRY</topic><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CARE OF BIRDS, FISHES, INSECTS</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>COMPOSITIONS THEREOF</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>FISHING</topic><topic>FORESTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HUNTING</topic><topic>HYGIENE</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>NEW BREEDS OF ANIMALS</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PHYSICS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>TESTING</topic><topic>TRAPPING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>EISENHARDT, GISELA</creatorcontrib><creatorcontrib>HIRSCHFELD, KIRSTEN</creatorcontrib><creatorcontrib>KORNAU, HANSRISTIAN</creatorcontrib><creatorcontrib>KUNER, ROHINI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>EISENHARDT, GISELA</au><au>HIRSCHFELD, KIRSTEN</au><au>KORNAU, HANSRISTIAN</au><au>KUNER, ROHINI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>METABOTROPIC GABA RECEPTOR COMPLEX ISSUED FROM THE CENTRAL NERVOUS SYSTEM</title><date>2000-03-23</date><risdate>2000</risdate><abstract>The invention relates to isolated proteins which code for metabotropic GABA receptors and which, together with GABAB receptor proteins, form a metabotropic GABA receptor complex (= protein heteromer). The invention also relates to nucleic acid sequences or recombinant nucleic acid constructs whi ch code for the proteins. In addition, the invention relates to host organisms or transgenic animals containing the nucleic acid sequences or the recombinant nucleic acid constructs and to monoclonal or polyclonal antibodies which are directed against the isolated proteins. The invention also relates to a meth od for locating substances with a specific affinity to binding to the inventive novel GABA receptors or to the inventive GABA receptor complexes, to a metho d for qualitatively or quantitatively detecting the inventive nucleic acid sequences or the inventive proteins, and to a method for locating substances which specifically bind to an inventive GABA receptor or to an inventive nucleic acid sequence. The invention also relates to the use of the nucleic acid sequences and proteins. Finally, the invention relates to substances wi th which the activity of metabotropic GABA receptors can be influenced by influencing the stability of the protein heteromer.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY CARE OF BIRDS, FISHES, INSECTS CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NEW BREEDS OF ANIMALS ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING TRAPPING VINEGAR WINE |
| title | METABOTROPIC GABA RECEPTOR COMPLEX ISSUED FROM THE CENTRAL NERVOUS SYSTEM |
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