CYCLOPHOSPHAMIDE FILM-COATED TABLETS

The invention relates to coated tablets having cyclophosphamide as active substance, containing in the core cyclophosphamide, one or more fillers, one or several dry binding agents but no pre-swollen starches, flow regulation agents and lubricants. In a preferred embodiment of the invention, the cor...

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Bibliographische Detailangaben
Hauptverfasser: SAUERBIER, DIETER, ENGEL, JURGEN, RAWERT, JURGEN, WICHERT, BURKHARD
Format: Patent
Sprache:eng ; fre
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Beschreibung
Zusammenfassung:The invention relates to coated tablets having cyclophosphamide as active substance, containing in the core cyclophosphamide, one or more fillers, one or several dry binding agents but no pre-swollen starches, flow regulation agents and lubricants. In a preferred embodiment of the invention, the core of the film tablet contains lactose monohydrate. D- mannite or CaHPO4 as fillers, non-pre-swollen corn starch or micro fine cellulose as dry binding agents, highly dispersed silicon oxide a s flow regulation agents and magnesium stearate, stearic acid, glycerin palmitostearate, polyethylene glycol, talc or glycerin monobehenate as lubricants.