A METHOD OF IMPROVED MIXING IN ROLLER BOTTLES

A method for enhancing the mixing of materials in roller bottle by the introduction of controlled axial and cross-sectional flow perturbations is disclosed. The effectiveness of the method is demonstrated by achieving higher efficiency in cell culturing and virus propagation in roller bottles by int...

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Bibliographische Detailangaben
Hauptverfasser: MUZZIO, FERNANDO J, SEARLES, JAMES A, BRAMBLE, JOYE L
Format: Patent
Sprache:eng ; fre
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Zusammenfassung:A method for enhancing the mixing of materials in roller bottle by the introduction of controlled axial and cross-sectional flow perturbations is disclosed. The effectiveness of the method is demonstrated by achieving higher efficiency in cell culturing and virus propagation in roller bottles by introducing controlled flow perturbations during the process.