PYRIMIDINE DERIVATIVES AND GUANINE DERIVATIVES, AND THEIR USE IN TREATING TUMOUR CELLS

The invention provides compounds exhibiting the ability to deplete O6- alkylguanine-DNA alkyltransferase (ATase) activity in tumour cells. The compounds include certain pyrimidine derivatives of formula (II), wherein R is (i) a cyclic group having at least one 5- or 6-membered heterocyclic ring, opt...

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Hauptverfasser:	ELDER, RHODERICK HUGH, CAROLA, CHRISTOPHE, MCMURRY, THOMAS BRIAN HAMILTON, MIDDLETON, MARK ROSS, MCCORMICK, JOAN ELIZABETH, MCELHINNEY, ROBERT STANLEY, WILLINGTON, MARK ANDREW, WATSON, AMANDA JEAN, MARGISON, GEOFFREY PAUL, DONNELLY, DOROTHY JOSEPHINE, KELLY, JANE, MURRAY, PAUL, RAFFERTY, JOSEPH ANTHONY
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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