HETEROCYCLE-FUSED THIAZOLE DERIVATIVES

A thiazole compound represented by the following general formula (I): wherein, R is a hydrogen atom, or a methyl, ethyl, isopropyl, aryl, phenyl, benzyl, or guanidinyl group, or an amino group having the general formula: NR3R4 in which R3 and R4, identical to or different from each other, represent independently a hydrogen atom, or a methyl, ethyl, butyl, isopropyl, aryl, cyclopropyl, cyclohexyl, phenyl, benzyl, pyridine, piperidine, or 4-methyl piperidine group; R1 and R2, identical to or different from each other, are independently a hydrogen atom, a hydroxy group, a C1-C6 lower alkyl group, a phenyl group having one substituent selected from a group consisting of a C1-C4 lower alkyl group, C1-C4 lower alkoxy group, a halogen atom, a nitro and a cyano group, a C1-C5 alkylphenyl group, or a pyridine group; R5, R6, R7 and R8, identical to or different from each other, are independently a hydrogen atom, a hydroxy group, a C1-C4 lower alkyl group, C1-C4 lower alkoxy group, phenyl group, or a phenyl group substituted with a C1-C4 alkyl group, a C1-C4 alkoxy group or a halogen atom, or a C1-C3 alkylphenyl group with the proviso that R7 is not H nor CH3 when Het is a 5-membered unsaturated oxygen-containing monocyclic group; and Het is selected from the group consisting of thiazole, imidazothiazole, benzimidazothiazole, imidazopyridine and triazolothiazole group, or a pharmaceutically acceptable salt thereof are disclosed. These compounds show excellent anti-ulcer activity.