BORONIC ACID AND ESTER INHIBITORS OF THROMBIN

Novel boronic acid and ester and carboxyl-modified amino acid compounds of formula (I): R1-Z-CHR1-A, which are inhibitors of trypsin-like enzymes, are disclosed, where R1, Z, R2 and A are defined within.

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Bibliographische Detailangaben
Hauptverfasser:	WITYAK, JOHN, MILLER, WILLIAM HENRY, DUNCIA, JOHN JONAS VYTAUTAS, AMPARO, EUGENE CRUZ, PACOFSKY, GREGORY JAMES, WEBER, PATRICIA CAROL, SANTELLA, JOSEPH BASIL III
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:	Novel boronic acid and ester and carboxyl-modified amino acid compounds of formula (I): R1-Z-CHR1-A, which are inhibitors of trypsin-like enzymes, are disclosed, where R1, Z, R2 and A are defined within.