PROCESS FOR PREPARING OLIGOPEPTIDE ALDEHYDES

PROCESS FOR PREPARING OLIGOPEPTIDE ALDEHYDES

The invention relates to a process for preparing oligopeptide aldehydes, which comprises dissolving an oligopeptide alcohol, which is reversibly protected at the N-terminal end, in a buffered solvent mixture comprising a nonoxidizable, polar, water-immiscible solvent and a little water, adding a sto...

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Hauptverfasser: RYBCZYNSKI, WOLFGANG, KEBETAELER, KURT
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Sprache:eng ; fre
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CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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creator RYBCZYNSKI, WOLFGANG
KEBETAELER, KURT
description The invention relates to a process for preparing oligopeptide aldehydes, which comprises dissolving an oligopeptide alcohol, which is reversibly protected at the N-terminal end, in a buffered solvent mixture comprising a nonoxidizable, polar, water-immiscible solvent and a little water, adding a stoichiometric quantity of sodium bromide, oxidizing the alcohol, while cooling, with a catalytic quantity of 2,2,6,6-tetramethylpiperidin-N-oxyl (TEMPO), or a derivative thereof, treating the reaction suspension with an aqueous solution of sodium hypochlorite, and finally terminating the reaction by adding a reducing agent. The oligopeptide aldehydes which have been prepared in this way are to be used in detergents.
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subjects CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
title PROCESS FOR PREPARING OLIGOPEPTIDE ALDEHYDES
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