TRICYCLIC AMIDE AND UREA COMPOUNDS USEFUL FOR INHIBITION OF G-PROTEIN FUNCTION AND FOR TREATMENT OF PROLIFERATIVE DISEASES
A method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells is disclosed. The method comprises the administration of a compound of formula (1.0) to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being. No...
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| creator | MALLAMS, ALAN K PETRIN, JOANNE M BISHOP, W. ROBERT TAVERAS, ARTHUR G REMISZEWSKI, STACY W NJOROGE, F. GEORGE WOLIN, RONALD L DOLL, RONALD J PIWINSKI, JOHN J |
| description | A method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells is disclosed. The method comprises the administration of a compound of formula (1.0) to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being. Novel compounds of formulae (5.0, 5.1, 5. 2, 5.3, 5.3A and 5.3B) are disclosed. Also disclosed are processes for making 3-substituted compounds of formulae (5.0, 5.1, 5.2 and 5.3). Further disclosed are novel compounds which are intermediates in the process for making 3-substituted compounds of formulae (5.0, 5.1, 5.2 and 5.3). |
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GEORGE ; WOLIN, RONALD L ; DOLL, RONALD J ; PIWINSKI, JOHN J</creator><creatorcontrib>MALLAMS, ALAN K ; PETRIN, JOANNE M ; BISHOP, W. ROBERT ; TAVERAS, ARTHUR G ; REMISZEWSKI, STACY W ; NJOROGE, F. GEORGE ; WOLIN, RONALD L ; DOLL, RONALD J ; PIWINSKI, JOHN J</creatorcontrib><description>A method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells is disclosed. The method comprises the administration of a compound of formula (1.0) to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being. Novel compounds of formulae (5.0, 5.1, 5. 2, 5.3, 5.3A and 5.3B) are disclosed. Also disclosed are processes for making 3-substituted compounds of formulae (5.0, 5.1, 5.2 and 5.3). Further disclosed are novel compounds which are intermediates in the process for making 3-substituted compounds of formulae (5.0, 5.1, 5.2 and 5.3).</description><edition>6</edition><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2004</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040120&DB=EPODOC&CC=CA&NR=2174104C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040120&DB=EPODOC&CC=CA&NR=2174104C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MALLAMS, ALAN K</creatorcontrib><creatorcontrib>PETRIN, JOANNE M</creatorcontrib><creatorcontrib>BISHOP, W. 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Further disclosed are novel compounds which are intermediates in the process for making 3-substituted compounds of formulae (5.0, 5.1, 5.2 and 5.3).</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2004</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFzMEKwjAQBNBePIj6De4PFKwKnuNmYxfapCQbwVMpEk-ihXry623Fu6eB4c3Ms7d4xgtWjKBq1gTKaoieFKCrGxetDhADmViBcR7YlnxkYWfBGTjljXdCbMFEi992mk9QxgupycrkRlWxIa-EzwSaA6lAYZnNbt19SKtfLrK1IcEyT_2zTUPfXdMjvVpU2-KwLzZ73P0XHxqdOZM</recordid><startdate>20040120</startdate><enddate>20040120</enddate><creator>MALLAMS, ALAN K</creator><creator>PETRIN, JOANNE M</creator><creator>BISHOP, W. 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GEORGE ; WOLIN, RONALD L ; DOLL, RONALD J ; PIWINSKI, JOHN J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2174104C3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2004</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>MALLAMS, ALAN K</creatorcontrib><creatorcontrib>PETRIN, JOANNE M</creatorcontrib><creatorcontrib>BISHOP, W. ROBERT</creatorcontrib><creatorcontrib>TAVERAS, ARTHUR G</creatorcontrib><creatorcontrib>REMISZEWSKI, STACY W</creatorcontrib><creatorcontrib>NJOROGE, F. GEORGE</creatorcontrib><creatorcontrib>WOLIN, RONALD L</creatorcontrib><creatorcontrib>DOLL, RONALD J</creatorcontrib><creatorcontrib>PIWINSKI, JOHN J</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MALLAMS, ALAN K</au><au>PETRIN, JOANNE M</au><au>BISHOP, W. ROBERT</au><au>TAVERAS, ARTHUR G</au><au>REMISZEWSKI, STACY W</au><au>NJOROGE, F. GEORGE</au><au>WOLIN, RONALD L</au><au>DOLL, RONALD J</au><au>PIWINSKI, JOHN J</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>TRICYCLIC AMIDE AND UREA COMPOUNDS USEFUL FOR INHIBITION OF G-PROTEIN FUNCTION AND FOR TREATMENT OF PROLIFERATIVE DISEASES</title><date>2004-01-20</date><risdate>2004</risdate><abstract>A method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells is disclosed. The method comprises the administration of a compound of formula (1.0) to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being. Novel compounds of formulae (5.0, 5.1, 5. 2, 5.3, 5.3A and 5.3B) are disclosed. Also disclosed are processes for making 3-substituted compounds of formulae (5.0, 5.1, 5.2 and 5.3). Further disclosed are novel compounds which are intermediates in the process for making 3-substituted compounds of formulae (5.0, 5.1, 5.2 and 5.3).</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | TRICYCLIC AMIDE AND UREA COMPOUNDS USEFUL FOR INHIBITION OF G-PROTEIN FUNCTION AND FOR TREATMENT OF PROLIFERATIVE DISEASES |
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