PROCESS FOR THE PREPARATION OF A C1-ESTERASE INHIBITOR CONCENTRATE (C1-INH) AND CONCENTRATE THUS OBTAINED, FOR THERAPEUTIC USES

L'invention concerne un procédé de préparation d'un concentré d'inhibiteur de la C1-estérase, d'origine plasmatique humain, qui comprend 2 séparations par chromatographie sur gels échangeurs d'ions de type tentaculaire. Le concentré de C1-INH peut être utilisé en thérapie de...

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Hauptverfasser: POULLE, MICHEL, BURNOUF, MIRYANA
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BURNOUF, MIRYANA
description L'invention concerne un procédé de préparation d'un concentré d'inhibiteur de la C1-estérase, d'origine plasmatique humain, qui comprend 2 séparations par chromatographie sur gels échangeurs d'ions de type tentaculaire. Le concentré de C1-INH peut être utilisé en thérapie de remplacement dans les angioedèmes héréditaires et d'autres pathologies où un processus d'inflammation est impliqué. A concentrate of C1-esterase inhibitor (C1-INH) is prepd. by a two stage column chromatography sepn., using tentacular ion exchange gels, the first being a weak anion exchanger and the second a strong cation exchanger.
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subjects BEER
BIOCHEMISTRY
CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
DISINFECTION, STERILISATION, OR DEODORISATION OF AIR
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES
MEDICAL OR VETERINARY SCIENCE
METALLURGY
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
title PROCESS FOR THE PREPARATION OF A C1-ESTERASE INHIBITOR CONCENTRATE (C1-INH) AND CONCENTRATE THUS OBTAINED, FOR THERAPEUTIC USES
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