PROCESS FOR THE PRODUCTION OF PURINES
In order to produce a purine of the general formula (I), (I) in which R1 and R2 can be the same or different and denote H, OH, SH, NH2, N-(di)-alkyl, halogen, O-alkyl, S-alkyl, alkyl or aryl and alkyl represents an aliphatic residue with 1 to 4 carbon atoms and aryl represents a phenyl residue which...
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| creator | GRAEFE, JUERGEN THALHAMMER, FRANZ |
| description | In order to produce a purine of the general formula (I), (I) in which R1 and R2 can be the same or different and denote H, OH, SH, NH2, N-(di)-alkyl, halogen, O-alkyl, S-alkyl, alkyl or aryl and alkyl represents an aliphatic residue with 1 to 4 carbon atoms and aryl represents a phenyl residue which is substituted if desired by CH3, OH, NH2 or halogen, from the corresponding 4-amino-5-nitrosopyrimidine of formula (II), (II) in which R1 and R2 have the above-mentioned meaning, the compound of formula (II) is reductively formylated in a solvent at a temperature of 80 to 220.degree.C in the presence of formic acid and a catalyst based on a noble metal and the 4-amino-5-formylaminopyrimidine formed as an intermediate is cyclized. |
| format | Patent |
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fre</language><subject>APPARATUS THEREFOR ; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY ; CHEMISTRY ; GENERAL METHODS OF ORGANIC CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PERFORMING OPERATIONS ; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; THEIR RELEVANT APPARATUS ; TRANSPORTING</subject><creationdate>1995</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19951229&DB=EPODOC&CC=CA&NR=2152722A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19951229&DB=EPODOC&CC=CA&NR=2152722A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GRAEFE, JUERGEN</creatorcontrib><creatorcontrib>THALHAMMER, FRANZ</creatorcontrib><title>PROCESS FOR THE PRODUCTION OF PURINES</title><description>In order to produce a purine of the general formula (I), (I) in which R1 and R2 can be the same or different and denote H, OH, SH, NH2, N-(di)-alkyl, halogen, O-alkyl, S-alkyl, alkyl or aryl and alkyl represents an aliphatic residue with 1 to 4 carbon atoms and aryl represents a phenyl residue which is substituted if desired by CH3, OH, NH2 or halogen, from the corresponding 4-amino-5-nitrosopyrimidine of formula (II), (II) in which R1 and R2 have the above-mentioned meaning, the compound of formula (II) is reductively formylated in a solvent at a temperature of 80 to 220.degree.C in the presence of formic acid and a catalyst based on a noble metal and the 4-amino-5-formylaminopyrimidine formed as an intermediate is cyclized.</description><subject>APPARATUS THEREFOR</subject><subject>CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>GENERAL METHODS OF ORGANIC CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PERFORMING OPERATIONS</subject><subject>PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>THEIR RELEVANT APPARATUS</subject><subject>TRANSPORTING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1995</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFANCPJ3dg0OVnDzD1II8XBVAPJdQp1DPP39FPzdFAJCgzz9XIN5GFjTEnOKU3mhNDeDgptriLOHbmpBfnxqcUFicmpeakm8s6ORoamRuZGRo6ExEUoAXvoixQ</recordid><startdate>19951229</startdate><enddate>19951229</enddate><creator>GRAEFE, JUERGEN</creator><creator>THALHAMMER, FRANZ</creator><scope>EVB</scope></search><sort><creationdate>19951229</creationdate><title>PROCESS FOR THE PRODUCTION OF PURINES</title><author>GRAEFE, JUERGEN ; THALHAMMER, FRANZ</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2152722A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>1995</creationdate><topic>APPARATUS THEREFOR</topic><topic>CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>GENERAL METHODS OF ORGANIC CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PERFORMING OPERATIONS</topic><topic>PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>THEIR RELEVANT APPARATUS</topic><topic>TRANSPORTING</topic><toplevel>online_resources</toplevel><creatorcontrib>GRAEFE, JUERGEN</creatorcontrib><creatorcontrib>THALHAMMER, FRANZ</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>GRAEFE, JUERGEN</au><au>THALHAMMER, FRANZ</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PROCESS FOR THE PRODUCTION OF PURINES</title><date>1995-12-29</date><risdate>1995</risdate><abstract>In order to produce a purine of the general formula (I), (I) in which R1 and R2 can be the same or different and denote H, OH, SH, NH2, N-(di)-alkyl, halogen, O-alkyl, S-alkyl, alkyl or aryl and alkyl represents an aliphatic residue with 1 to 4 carbon atoms and aryl represents a phenyl residue which is substituted if desired by CH3, OH, NH2 or halogen, from the corresponding 4-amino-5-nitrosopyrimidine of formula (II), (II) in which R1 and R2 have the above-mentioned meaning, the compound of formula (II) is reductively formylated in a solvent at a temperature of 80 to 220.degree.C in the presence of formic acid and a catalyst based on a noble metal and the 4-amino-5-formylaminopyrimidine formed as an intermediate is cyclized.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | APPARATUS THEREFOR CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES THEIR RELEVANT APPARATUS TRANSPORTING |
| title | PROCESS FOR THE PRODUCTION OF PURINES |
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