PROCESS FOR THE PRODUCTION OF PURINES

In order to produce a purine of the general formula (I), (I) in which R1 and R2 can be the same or different and denote H, OH, SH, NH2, N-(di)-alkyl, halogen, O-alkyl, S-alkyl, alkyl or aryl and alkyl represents an aliphatic residue with 1 to 4 carbon atoms and aryl represents a phenyl residue which...

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Bibliographische Detailangaben
Hauptverfasser:	GRAEFE, JUERGEN, THALHAMMER, FRANZ
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	APPARATUS THEREFOR CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES THEIR RELEVANT APPARATUS TRANSPORTING
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Beschreibung
Zusammenfassung:	In order to produce a purine of the general formula (I), (I) in which R1 and R2 can be the same or different and denote H, OH, SH, NH2, N-(di)-alkyl, halogen, O-alkyl, S-alkyl, alkyl or aryl and alkyl represents an aliphatic residue with 1 to 4 carbon atoms and aryl represents a phenyl residue which is substituted if desired by CH3, OH, NH2 or halogen, from the corresponding 4-amino-5-nitrosopyrimidine of formula (II), (II) in which R1 and R2 have the above-mentioned meaning, the compound of formula (II) is reductively formylated in a solvent at a temperature of 80 to 220.degree.C in the presence of formic acid and a catalyst based on a noble metal and the 4-amino-5-formylaminopyrimidine formed as an intermediate is cyclized.